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Eduardo Magalhães Rego

Eduardo Magalhães Rego

Pesquisa

O foco de nossa pesquisa é investigar a base molecular da leucemogênese. Como membro do Consórcio Internacional sobre Leucemia Aguda (ICAL), eu e minha equipe conduzimos ensaios clínicos explorando estratégias para diagnosticar e tratar pacientes, adaptando cada caso aos recursos locais. Investigamos o genoma, o transcriptoma e o proteoma para identificar moléculas relevantes para a patogênese e resposta ao tratamento da leucemia aguda. Os candidatos potenciais são testados usando células geneticamente modificadas e testes em camundongos  como modelos. Nossos estudos analisam não apenas as células leucêmicas, mas também o microambiente da medula óssea e o fluxo de informação célula a célula através das micropartículas. O uso de células geneticamente modificadas para terapia é uma das aplicações potenciais de nossa pesquisa.

Palavras-chave: leucemia, leucemia mieloide aguda, leucemogênese, mutação

PESQUISA

Professor Titular de Hematologia da Faculdade de Medicina da Universidade de São Paulo

ÁREAS DE PESQUISA

INFORMAÇÕES ADICIONAIS

Prêmios e Títulos

4th Latin American Novartis 4º Prêmio Científico Latino-Americano de Oncologia da Novartis, Novartis América Latina. Função: Supervisor (2011) Scientific Award, Novartis Latin America. Role: Supervisor (2011)

Apresentação em Sessão Plenária (6 melhores resumos) do Encontro da Sociedade Americana de Hematologia (ASH) 2012, Atlanta, GA, EUA - Papel: Apresentador, autor (2012)

Publicações Selecionadas

Thomé CH, Ferreira GA, Pereira-Martins DA, Dos Santos GA, Ortiz CA, de Souza LEB, Sobral LM, Silva CLA, Scheucher PS, Gil CD, Leopoldino AM, Silveira DRA, Coelho-Silva JL, Traina F, Koury LC, Melo RAM, Bittencourt R, Pagnano K, Pasquini R, Nunes EC, Fagundes EM, Gloria ABF, Kerbauy FR, Chauffaille ML, Keating A, Tallman MS, Ribeiro RC, Dillon R, Ganser A, Löwenberg B, Valk P, Lo-Coco F, Sanz MA, Berliner N, Faça VM, Rego EM. NTAL is associated with treatment outcome, cell proliferation and differentiation in acute promyelocytic leukemia. Sci Rep. 2020 Jun 25;10(1):10315. PMID: 32587277; PMCID: PMC7316767.

Weinhäuser I, Pereira-Martins DA, Ortiz C, Silveira DR, Simões LAA, Bianco TM, Araujo CL, Koury LC, Melo RAM, Bittencourt RI, Pagnano K, Pasquini R, Nunes EC, Fagundes EM, Gloria AB, Kerbauy F, Chauffaille ML, Keating A, Tallman MS, Ribeiro RC, Dillon R, Ganser A, Löwenberg B, Valk P, Lo-Coco F, Sanz MA, Berliner N, Ammatuna E, Lucena-Araujo AR, Schuringa JJ, Rego EM. Reduced SLIT2 is Associated with Increased Cell Proliferation and Arsenic Trioxide Resistance in Acute Promyelocytic Leukemia. Cancers (Basel). 2020 Oct 27;12(11):3134.

Barna, M., Pusic, A., Zollo, O. , Costa, M., Kondrashov, N.,  Rego, E., Rao, P.H.,  Ruggero, D.. Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency. Nature 2008; 456, 971–975.

Rego EM, Kim HT, Ruiz-Argüelles GJ, Undurraga MS, Uriarte Mdel R, Jacomo RH, Gutiérrez- Aguirre H, Melo RA, Bittencourt R, Pasquini R, Pagnano K, Fagundes EM, Chauffaille Mde L, Chiattone CS, Martinez L, Meillón LA, Gómez-Almaguer D, Kwaan HC, Garcés-Eisele J, Gallagher R, Niemeyer CM, Schrier SL, Tallman M, Grimwade D, Ganser A, Berliner N,, Ribeiro RC, Lo-Coco F, Löwenberg B, Sanz MA. Improving acute promyelocytic leukemia (APL) outcome in developing countries through networking, results of the International Consortium on APL. Blood. 2013;121(11):1935-43

Rego EM, Wang ZG, Peruzzi D, He LZ, Cordon-Cardo C, Pandolfi PP. Role of promyelocytic leukemia (PML) protein in tumor suppression. J Exp Med. 2001;193(4):521-29.

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