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José Mauricio Mota

José Mauricio Mota

Nosso grupo investiga aspectos relacionados a imunologia e microambiente tumoral, assim como novos tratamentos e biomarcadores para neoplasias geniturinárias (câncer de próstata, bexiga, rim, testículo e pênis) através de pesquisas clínicas e translacionais. Tenho Doutorado em Oncologia pela Universidade de São Paulo e Pós-doutorado/Advanced Clinical Fellowship pelo Memorial Sloan Kettering Cancer Center. Atualmente, atuo como médico titular da Oncologia D’Or e chefe do Grupo de Tumores Geniturinários do Serviço de Oncologia do Instituto do Câncer do Estado de São Paulo (ICESP-FMUSP).

Palavras-chave: microambiente tumoral, imunoterapia, câncer de próstata, câncer de rim, câncer de bexiga

 

 

PESQUISA

Pós-doutorado/Advanced Clinical Fellowship, Memorial Sloan Kettering Cancer Center, Nova Iorque, EUA

Doutor em Oncologia pela Universidade de São Paulo

Residência Médica em Oncologia pelo Instituto do Câncer do Estado de São Paulo, Universidade de São Paulo

ÁREAS DE PESQUISA

INFORMAÇÕES ADICIONAIS

Prêmios e Títulos

Prêmio Octavio Frias de Oliveira 2020, Instituto do Câncer do Estado de São Paulo (co-autor).

Prêmio Octavio Frias de Oliveira 2019 (Segundo Lugar), Instituto do Câncer do Estado de São Paulo (co-autor).

ASCO in-training exam - maximum score (800/800); percentile 99, American Society of Clinical Oncology (2018).

ASCO in-training exam - maximum score (800/800), percentile 99, American Society of Clinical Oncology (2017).

Membro do Programa Jovens Lideranças Médicas da Associação Nacional de Medicina (2021-2026)

Publicações Selecionadas

Teo MY, Mota JM, Whiting KA, Li HA, Funt SA, Lee CH, Solit DB, Al-Ahmadie K, Milowsky MI, Balar AV, Pietzak E, Dalbagni G, Bochner BH, Ostrovnaya I, Bajorin DF, Rosenberg JE, Iyer G. Fibroblast Growth Factor Receptor 3 Alteration Status is Associated with Differential Sensitivity to Platinum-based Chemotherapy in Locally Advanced and Metastatic Urothelial Carcinoma. Eur Urol. 2020;78(6):907-915.

Mota JM, Leite CA, Souza LE, Melo PH, Nascimento DC, de-Deus-Wagatsuma V, Temporal J, Figueiredo F, Noushmehr H, Alves-Filho JC, Cunha FQ, Rego EM. Post-Sepsis State Induces Tumor-Associated Macrophage Accumulation through CXCR4/CXCL12 and Favors Tumor Progression in Mice. Cancer Immunol Res. 2016;4(4):312-22.

Zhang Z, Karthaus WR, Lee YS, Gao VR, Wu C, Russo JW, Liu M, Mota JM, Abida W, Linton E, Lee E, Barnes SD, Chen A, Mao N, Wongvipat J, Choi D, Chen X, Zhao H, Manova-Todorova K, Stanchina E, Taplin ME, Balk SP, Rathkopf DE, Gopalan A, Carver BS, Mu P, Jiang X, Watson PA, Sawyers CL. Tumor Microenvironment-Derived NRG1 Promotes Antiandrogen Resistance in Prostate Cancer. Cancer Cell. 2020;38(2):279-296.e9.

Mota JM, Barnett E, Nauseef J, Nguyen N, Stopsack KH, Wibmer A, Flynn JR, Heller F, Danila DC, Rathkopf D, Slovin S, Kantoff PW, Scher HI, Morris MJ, Schultz N, Solit DB, Abida W. Platinum-Based Chemotherapy in Metastatic Prostate Cancer With DNA Repair Gene Alterations. JCO Precis Oncol. 2020; 4:355-366.  Epub 2020 Apr 16.

Morris MJ, Mota JM, Lacuna K, Hilden P, Gleave M, Carducci MA, Saad F, Cohn ED, Filipenko J, Heller G, Shore N, Armstrong AJ, Scher HI. Phase 3 Randomized Controlled Trial of Androgen Deprivation Therapy with or Without Docetaxel in High-risk Biochemically Recurrent Prostate Cancer After Surgery (TAX3503). Eur Urol Oncol. 2021;4(4):543-552.