Com foco em pesquisas clínicas, a equipe de gastroenterologia do IDOR atua em conjunto com os serviços de gastroenterologia de toda a RDSL (Gastro D’Or) em projetos que buscam novas drogas para doença inflamatória intestinal, enteropatias eosinofílicas, doença celíaca e neoplasias do tubo digestivo.
Como acontece em outras áreas de pesquisa, a gastroenterologia se dedica tanto a projetos próprios quanto à realização de ensaios clínicos patrocinados pela indústria farmacêutica. Os testes clínicos incluem experimentos com novas drogas, pesquisas de reposicionamento de medicamentos já disponíveis no mercado e comparações entre dois ou mais tratamentos disponíveis para uma mesma condição.
Recentemente, o IDOR participou de um estudo sobre eficácia, a longo prazo, de um medicamento contra a doença de Crohn em pacientes graves, que já haviam usado outras terapias. Em outro projeto, a equipe está fazendo um levantamento demográfico do perfil dos pacientes com doença inflamatória intestinal atendidos pela RDSL.
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JAK selectivity for inflammatory bowel disease treatment: does it clinically matter? Danese S, Argollo M, Le Berre C, Peyrin-Biroulet L.Gut. 2019 Oct;68(10):1893-1899.
Optimizing biologic therapy in IBD: how essential is therapeutic drug monitoring?Argollo M, Kotze PG, Kakkadasam P, D’Haens G.Nat Rev Gastroenterol Hepatol. 2020 Nov;17(11):702-710.
Comorbidities in inflammatory bowel disease: a call for action. Argollo M, Gilardi D, Peyrin-Biroulet C, Chabot JF, Peyrin-Biroulet L, Danese S.Lancet Gastroenterol Hepatol. 2019 Aug;4(8):643-654.
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Amaral MVFD, Guimarães JR, Volpe P, Oliveira FMM, Domene CE, Roll S, Cavazzola LT. Robotic Transversus Abdominis Release (TAR): is it possible to offer minimally invasive surgery for abdominal wall complex defects? Rev Col Bras Cir. 2017 Mar-Apr;44(2):216-219. English, Portuguese. PMID: 28658342.
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