array(63) { ["SERVER_SOFTWARE"]=> string(6) "Apache" ["REQUEST_URI"]=> string(47) "/instituto/idorpost_scientists/clarissa-gurgel/" ["PHP_PATH"]=> string(24) "/opt/bitnami/php/bin/php" ["FREETDSLOCALES"]=> string(0) "" ["FREETDSCONF"]=> string(0) "" ["OPENSSL_ENGINES"]=> string(31) "/opt/bitnami/common/lib/engines" ["OPENSSL_CONF"]=> string(39) "/opt/bitnami/common/openssl/openssl.cnf" ["SSL_CERT_FILE"]=> string(52) "/opt/bitnami/common/openssl/certs/curl-ca-bundle.crt" ["CURL_CA_BUNDLE"]=> string(52) "/opt/bitnami/common/openssl/certs/curl-ca-bundle.crt" ["LDAPCONF"]=> string(42) "/opt/bitnami/common/etc/openldap/ldap.conf" ["GS_LIB"]=> string(43) "/opt/bitnami/common/share/ghostscript/fonts" ["MAGICK_CODER_MODULE_PATH"]=> string(60) "/opt/bitnami/common/lib/ImageMagick-6.9.8/modules-Q16/coders" ["MAGICK_CONFIGURE_PATH"]=> string(73) "/opt/bitnami/common/lib/ImageMagick-6.9.8/config-Q16:/opt/bitnami/common/" ["MAGICK_HOME"]=> string(19) "/opt/bitnami/common" ["PATH"]=> string(260) "/opt/bitnami/apps/wordpress/bin:/opt/bitnami/varnish/bin:/opt/bitnami/sqlite/bin:/opt/bitnami/php/bin:/opt/bitnami/mysql/bin:/opt/bitnami/letsencrypt/:/opt/bitnami/apache2/bin:/opt/bitnami/common/bin:/usr/local/sbin:/usr/local/bin:/usr/sbin:/usr/bin:/sbin:/bin" ["USER"]=> string(6) "daemon" ["HOME"]=> string(9) "/usr/sbin" ["SCRIPT_NAME"]=> string(10) "/index.php" ["QUERY_STRING"]=> string(0) "" ["REQUEST_METHOD"]=> string(3) "GET" ["SERVER_PROTOCOL"]=> string(8) "HTTP/1.0" ["GATEWAY_INTERFACE"]=> string(7) "CGI/1.1" ["REDIRECT_URL"]=> string(47) "/instituto/idorpost_scientists/clarissa-gurgel/" ["REMOTE_PORT"]=> string(5) "13581" ["SCRIPT_FILENAME"]=> string(44) "/opt/bitnami/apps/wordpress/htdocs/index.php" ["SERVER_ADMIN"]=> string(15) "[email protected]" ["CONTEXT_DOCUMENT_ROOT"]=> string(34) "/opt/bitnami/apps/wordpress/htdocs" ["CONTEXT_PREFIX"]=> string(0) "" ["REQUEST_SCHEME"]=> string(4) "http" ["DOCUMENT_ROOT"]=> string(34) "/opt/bitnami/apps/wordpress/htdocs" ["REMOTE_ADDR"]=> string(13) "15.228.198.21" ["SERVER_PORT"]=> string(2) "80" ["SERVER_ADDR"]=> string(11) "172.26.1.14" ["SERVER_NAME"]=> string(13) "54.225.48.228" ["SERVER_SIGNATURE"]=> string(0) "" ["LD_LIBRARY_PATH"]=> string(410) "/opt/bitnami/sqlite/lib:/opt/bitnami/mysql/lib:/opt/bitnami/apache2/lib:/opt/bitnami/common/lib:/opt/bitnami/sqlite/lib:/opt/bitnami/mysql/lib:/opt/bitnami/apache2/lib:/opt/bitnami/common/lib:/opt/bitnami/varnish/lib:/opt/bitnami/varnish/lib/varnish:/opt/bitnami/varnish/lib/varnish/vmods:/opt/bitnami/sqlite/lib:/opt/bitnami/mysql/lib:/opt/bitnami/apache2/lib:/opt/bitnami/common/lib:/opt/bitnami/common/lib64" ["HTTP_ACCEPT_LANGUAGE"]=> string(14) "en-US,en;q=0.5" ["HTTP_ACCEPT"]=> string(63) "text/html,application/xhtml+xml,application/xml;q=0.9,*/*;q=0.8" ["HTTP_USER_AGENT"]=> string(40) "CCBot/2.0 (https://commoncrawl.org/faq/)" ["HTTP_CF_VISITOR"]=> string(22) "{\"scheme\":\"https\"}" ["HTTP_CF_IPCOUNTRY"]=> string(2) "US" ["HTTP_TRUE_CLIENT_IP"]=> string(13) "3.236.142.143" ["HTTP_CF_RAY"]=> string(20) "898a13a5dfaf0852-GRU" ["HTTP_ACCEPT_ENCODING"]=> string(8) "gzip, br" ["HTTP_CDN_LOOP"]=> string(10) "cloudflare" ["HTTP_CF_CONNECTING_IP"]=> string(13) "3.236.142.143" ["HTTP_X_AMZN_TRACE_ID"]=> string(40) "Root=1-6678fa3e-678e5fcd25702c71250a7fd2" ["HTTP_X_FORWARDED_PORT"]=> string(3) "443" ["HTTP_CONNECTION"]=> string(5) "close" ["HTTP_X_FORWARDED_PROTO"]=> string(4) "http" ["HTTP_X_FORWARDED_FOR"]=> string(44) "3.236.142.143, 172.71.234.212, 10.247.45.207" ["HTTP_X_REAL_IP"]=> string(13) "10.247.45.207" ["HTTP_X_FORWARDED_HOST"]=> string(25) "www.rededorsaoluiz.com.br" ["HTTP_HOST"]=> string(13) "54.225.48.228" ["SCRIPT_URI"]=> string(67) "http://54.225.48.228/instituto/idorpost_scientists/clarissa-gurgel/" ["SCRIPT_URL"]=> string(47) "/instituto/idorpost_scientists/clarissa-gurgel/" ["REDIRECT_STATUS"]=> string(3) "200" ["REDIRECT_SCRIPT_URI"]=> string(67) "http://54.225.48.228/instituto/idorpost_scientists/clarissa-gurgel/" ["REDIRECT_SCRIPT_URL"]=> string(47) "/instituto/idorpost_scientists/clarissa-gurgel/" ["FCGI_ROLE"]=> string(9) "RESPONDER" ["PHP_SELF"]=> string(10) "/index.php" ["REQUEST_TIME_FLOAT"]=> float(1719204415.0133) ["REQUEST_TIME"]=> int(1719204415) }

Clarissa Gurgel

Clarissa Gurgel

A pesquisa translacional em oncologia tem sido o foco principal da equipe que lidero. Atualmente, nossos estudos envolvem modelos celulares in vitro (ex: esferóides tumorais) e estratégias in silico (modelagem computacional e inteligência artificial) para a identificação de alvos moleculares drogáveis e candidatos a compostos antitumorais, incluindo produtos naturais. Na área de estudo da biologia tumoral, nossa equipe está especialmente interessada no estudo de eventos complexos no câncer, como a relação entre a interação celular homitípica e heterotípica com resistência terapêutica e prognóstico.

Palavras-chave: Biologia de Tumores; Compostos antitumorais; Modelagem Computacional em Oncologia; Modelos Celulares

PESQUISA

Pós-Doutorado em Biologia de Tumores

Doutorado em Patologia Humana - UFBA/FIOCRUZ

Mestrado em Patologia Humana - UFBA/FIOCRUZ

ÁREAS DE PESQUISA

INFORMAÇÕES ADICIONAIS

Prêmios e Títulos

Pesquisador CNPq - 2015 até os dias atuais

International Advanced Fellow Awardee, Newton Foundation, Reino Unido - 2020 - dias atuais

Membro afiliado da American Association for Cancer Research

Membro afiliado da Academy of Medical Science - Reino Unido

Publicações Selecionadas

Cavicchioli Buim ME, Gurgel CA, Gonçalves Ramos EA, Lourenço SV, Soares FA. Activation of sonic hedgehog signaling in oral squamous cell carcinomas: a preliminary study. Hum Pathol. 2011 Oct;42(10):1484-90. Epub 2011 Apr 14. PMID: 21496866.

Valverde Lde F, Pereira Tde A, Dias RB, Guimarães VS, Ramos EA, Santos JN, Gurgel Rocha CA. Macrophages and endothelial cells orchestrate tumor-associated angiogenesis in oral cancer via hedgehog pathway activation. Tumour Biol. 2016 Jul;37(7):9233-41. Epub 2016 Jan 15. PMID: 26768620.

Nogueira RLR, de Araújo TBS, Valverde LF, Silva VAO, Cavalcante BRR, Rossi EA, Allahdadi KJ, Dos Reis MG, Pereira TA, Coletta RD, Bezerra DP, de Freitas Souza BS, Dias RB, Rocha CAG. Arsenic Trioxide Triggers Apoptosis of Metastatic Oral Squamous Cells Carcinoma with Concomitant Downregulation of GLI1 in Hedgehog Signaling. Biomedicines. 2022 Dec 19;10(12):3293. PMID: 36552049; PMCID: PMC9775978.

Bacelar Sacramento de Araújo T, de Oliveira Siquara da Rocha L, Torres Andion Vidal M, Cerqueira Coelho PL, Galvão Dos Reis M, Solano de Freitas Souza B, Botelho Pereira Soares M, Almeida Pereira T, Della Coletta R, Pereira Bezerra D, Borges Dias R, Araújo Gurgel Rocha C. GANT61 Reduces Hedgehog Molecule (GLI1) Expression and Promotes Apoptosis in Metastatic Oral Squamous Cell Carcinoma Cells. Int J Mol Sci. 2020 Aug 24;21(17):6076. PMID: 32846867; PMCID: PMC7503713.

Siquara da Rocha LO, Souza BSF, Lambert DW, Gurgel Rocha CA. Cell-in-Cell Events in Oral Squamous Cell Carcinoma. Front Oncol. 2022 Jun 30;12:931092. PMID: 35847959; PMCID: PMC9280122.

Conteúdo Relacionado
Fale com a gente.