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Terapia Celular

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Terapia Celular

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Sediado na Bahia, o Centro de Biotecnologia e Terapia Celular (CBTC) do IDOR desenvolve pesquisas translacionais que possam alcançar impacto positivo na prática clínica.
Uma de suas linhas de pesquisa envolve os transtornos do espectro autista. Partindo do mapeamento genético de crianças com autismo na região de Salvador, os cientistas vêm estudando as alterações genéticas associadas a essa condição. Com uso de células-tronco de pluripotência induzida e organoides cerebrais, a equipe estuda como essas mutações genéticas impactam o desenvolvimento cerebral e procuram desenvolver novos métodos para reverter ou abrandar os transtornos do espectro autista por meio da terapia gênica e do uso de medicações à base de cannabis.

Na área de oncologia, os projetos do CBTC incluem o estudo dos mecanismos celulares envolvidos no desenvolvimento de metástases e na manutenção de células-tronco tumorais em pacientes com carcinoma escamocelular. Nos dois casos, os cientistas estão em busca de alvos para novas terapias antitumorais e tratamentos capazes de deter a disseminação do câncer.

O CBTC também trabalha para o desenvolvimento de novas terapias com células-tronco para recuperação neurológica de pacientes com lesões na medula (paraplégicos e tetraplégicos) e para o tratamento de anemia falciforme e outras doenças genéticas. Por fim, o grupo se dedica à criação de terapias celulares para tratar doenças crônicas do fígado e do coração, além do estudo dos mecanismos celulares do envelhecimento e ao desenvolvimento de estratégias para amenizar ou reverter os danos neurológicos que o acompanham.

Pesquisadores
Clarissa Gurgel

Terapia Celular
Verônica Fernandes Vianna

Patologia

Processamento e análise de imagens

Terapia Celular

Ortopedia
Rogério Passos

Terapia intensiva

Neurociência

Terapia Celular
Kyan James Allahdadi

Neurociência

Terapia Celular
Carolina Nonaka

Terapia Celular
Luciana Souza de Aragão França

Terapia Celular
Bruno Solano F. Souza

Terapia Celular
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Principais Publicações

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doi: 10.1002/cti2.1108

Leruste A, *Ramos RN, *Tosello J, Tauziède-Espariat A, Brohard S, Han ZY, Beccaria K, Andrianteranagna M, Caudana P, Nikolic J, Chauvin C, Niborski LL, Manriquez V, Richer W, Masliah-Planchon J, et al. Clonally Expanded T Cells Reveal Immunogenicity of Rhabdoid Tumors. Cancer Cell. 2019 Dec 9;36(6):597-612.e8. Epub 2019 Nov 7. PMID: 31708437. (*igual contribuição)

doi: 10.1016/j.ccell.2019.10.008

Bourdely P, Anselmi G, Vaivode K, Ramos RN, Missolo-Koussou Y, Hidalgo S, Tosselo J, Nuñez N, Richer W, Vincent-Salomon A, Saxena A, Wood K, Lladser A, Piaggio E, Helft J, Guermonprez P. Transcriptional and Functional Analysis of CD1c+ Human Dendritic Cells Identifies a CD163+ Subset Priming CD8+CD103+ T Cells. Immunity. 2020 Aug 18;53(2):335-352.e8. Epub 2020 Jun 30. PMID: 32610077; PMCID: PMC7445430.

doi: 10.1016/j.immuni.2020.06.002

Nader GPF, Agüera-Gonzalez S, Routet F, Gratia M, Maurin M, Cancila V, Cadart C, Palamidessi A, Ramos RN, San Roman M, Gentili M, Yamada A, Williart A, Lodillinsky C, Lagoutte E, Villard C, Viovy JL, Tripodo C, Galon J, Scita G, Manel N, Chavrier P, Piel M. Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion. Cell. 2021 Sep 30;184(20):5230-5246.e22. Epub 2021 Sep 21. PMID: 34551315.

doi: 10.1016/j.cell.2021.08.035

Nalio Ramos R, Missolo-Koussou Y, Gerber-Ferder Y, Bromley CP, Bugatti M, Núñez NG, Tosello Boari J, Richer W, Menger L, Denizeau J, Sedlik C, Caudana P, Kotsias F, Niborski LL, Viel S, Bohec M, Lameiras S, Baulande S, Lesage L, Nicolas A, Meseure D, Vincent-Salomon A, Reyal F, Dutertre CA, Ginhoux F, Vimeux L, Donnadieu E, Buttard B, Galon J, Zelenay S, Vermi W, Guermonprez P, Piaggio E, Helft J. Tissue-resident FOLR2+ macrophages associate with CD8+ T cell infiltration in human breast cancer. Cell. 2022 Mar 31;185(7):1189-1207.e25. Epub 2022 Mar 23. PMID: 35325594.

doi: 10.1016/j.cell.2022.02.021

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doi: 10.1186/s12879-021-06829-7

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doi: 10.1016/j.leukres.2019.06.001

Costa Neto A, Santos F, Ribeiro I, Oliveira V, Dezan M, Kashima S, Covas D, Pereira A, Fonseca G, Moreira F, Krieger J, Gualandro S, Rocha V, Mendrone A Jr, Dinardo CL. FcγR2B B2.4 haplotype predicts increased risk of red blood cell alloimmunization in sickle cell disease patients. Transfusion. 2020 Jul;60(7):1573-1578. Epub 2020 May 4. PMID: 32681817

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doi: 10.3390/cancers15010296

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doi: 10.3390/ma13184071

Santos ES, de Aragão-França LS, Meira CS, Cerqueira JV, Vasconcelos JF, Nonaka CKV, Pontes-de-Carvalho LC, Soares MBP. Tolerogenic Dendritic Cells Reduce Cardiac Inflammation and Fibrosis in Chronic Chagas Disease. Front Immunol. 2020 Apr 7;11:488. eCollection 2020.

doi: 10.3389/fimmu.2020.00488

da Silva KN, Pinheiro PCG, Gobatto ALN, Passos RDH, Paredes BD, França LSA, Nonaka CKV, Barreto-Duarte B, Araújo-Pereira M, Tibúrcio R, Cruz FF, Martins GLS, Andrade BB, de Castro-Faria-Neto HC, Rocco PRM, Souza BSF. Immunomodulatory and Anti-fibrotic Effects Following the Infusion of Umbilical Cord Mesenchymal Stromal Cells in a Critically Ill Patient With COVID-19 Presenting Lung Fibrosis: A Case Report. Front Med (Lausanne). 2021 Nov 17;8:767291. eCollection 2021.

doi: 10.3389/fmed.2021.767291

da Silva KN, Gobatto ALN, Costa-Ferro ZSM, Cavalcante BRR, Caria ACI, de Aragão França LS, Nonaka CKV, de Macêdo Lima F, Lopes-Pacheco M, Rocco PRM, de Freitas Souza BS. Is there a place for mesenchymal stromal cell-based therapies in the therapeutic armamentarium against COVID-19? Stem Cell Res Ther. 2021 Jul 27;12(1):425.

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Allahdadi KJ, de Santana TA, Santos GC, Azevedo CM, Mota RA, Nonaka CK, Silva DN, Valim CXR, Figueira CP, Dos Santos WLC, do Espirito Santo RF, Evangelista AF, Villarreal CF, Dos Santos RR, de Souza BSF, Soares MBP. IGF-1 overexpression improves mesenchymal stem cell survival and promotes neurological recovery after spinal cord injury. Stem Cell Res Ther. 2019 May 21;10(1):146. PMID: 31113444; PMCID: PMC6530133.

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Nonaka, C.K.V.; Sampaio, G.L.; de Aragão França, L.; Cavalcante, B.R.; Silva, K.N.; Khouri, R.; Torres, F.G.; Meira, C.S.; de Souza Santos, E.; Macedo, C.T.; Paredes, B.D.; Rocha, V.P.C.; Rogatto, S.R.; Ribeiro dos Santos, R.; Souza, B.S.d.F.; Soares, M.B.P. Therapeutic miR-21 Silencing Reduces Cardiac Fibrosis and Modulates Inflammatory Response in Chronic Chagas Disease. Int. J. Mol. Sci. 2021, 22, 3307.

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Nonaka CKV, Franco MM, Gräf T, de Lorenzo Barcia CA, de Ávila Mendonça RN, de Sousa KAF, Neiva LMC, Fosenca V, Mendes AVA, de Aguiar RS, Giovanetti M, de Freitas Souza BS. Genomic Evidence of SARS-CoV-2 Reinfection Involving E484K Spike Mutation, Brazil. Emerg Infect Dis. 2021 May;27(5):1522-1524. Epub 2021 Feb 19. PMID: 33605869; PMCID: PMC8084516.

doi: 10.3201/eid2705.210191
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