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Bruno Solano F. Souza

Bruno Solano F. Souza

Pesquisa

Nosso grupo realiza pesquisas com foco em: (i) desenvolvimento de terapias celulares e genéticas para as necessidades médicas ainda não atendidas; (ii) estudo de células-tronco pluripotentes induzidas derivadas de pacientes para modelar distúrbios do neurodesenvolvimento / distúrbios do espectro do autismo; (iii) utilização de métodos de biologia molecular aplicados à identificação de biomarcadores e diagnósticos clínicos. 

Nossa principal motivação é contribuir com a ciência translacional e com a melhoria de diagnósticos e tratamentos, trazendo nossos achados da bancada para a prática, combinando abordagens multidisciplinares, tecnologia de ponta, estudos pré-clínicos e clínicos.

Palavras-chave: terapia celular e gênica, iPSC, autismo, biomarcadores.

PESQUISA

Doutorado em Patologia pela Universidade Federal da Bahia

Mestrado em Biotecnologia pela Fundação Oswaldo Cruz - Fiocruz

Graduado em Medicina pela Universidade Federal da Bahia

ÁREAS DE PESQUISA

INFORMAÇÕES ADICIONAIS

Publicações Selecionadas

Souza BS, Sampaio GL, Pereira CS, Campos GS, Sardi SI, Freitas LA, Figueira CP, Paredes BD, Nonaka CK, Azevedo CM, Rocha VP, Bandeira AC, Mendez-Otero R, Dos Santos RR, Soares MB. Zika virus infection induces mitosis abnormalities and apoptotic cell death of human neural progenitor cells. Scientific reports 6 (1), 1-13. 2016. PMID: 28008958; PMCID: PMC5180086.

Sampaio GLA, Martins GLS, Paredes BD, Nonaka CKV, da Silva KN, Rossi EA, Dos Santos RR, Soares MBP, Souza BSF. Generation of an induced pluripotent stem cell line from a patient with autism spectrum disorder and SCN2A haploinsufficiency. Stem Cell Research. Volume 39, August 2019, 101488. Epub 2019 Jun 25. PMID: 31272037.

Orge ID, Gadd VL, Barouh JL, Rossi EA, Carvalho RH, Smith I, Allahdadi KJ, Paredes BD, Silva DN, Damasceno PKF, Sampaio GL, Forbes SJ, Soares MBP, Souza BSF. Phenotype instability of hepatocyte-like cells produced by direct reprogramming of mesenchymal stromal cells. Stem Cell Res Ther 11, 154 (2020). PMID: 32276654; PMCID: PMC7323614.

da Silva KN, Gobatto ALN, Costa-Ferro ZSM, Cavalcante BRR, Caria ACI, de Aragão França LS, Nonaka CKV, de Macêdo Lima F, Lopes-Pacheco M, Rocco PRM, de Freitas Souza BS. Is there a place for mesenchymal stromal cell-based therapies in the therapeutic armamentarium against COVID-19? Stem Cell Research & Therapy volume 12, Article number: 425 (2021). PMID: 34315546; PMCID: PMC8314259.

Nonaka CKV, Franco MM, Gräf T, de Lorenzo Barcia CA, de Ávila Mendonça RN, de Sousa KAF, Neiva LMC, Fosenca V, Mendes AVA, de Aguiar RS, Giovanetti M, de Freitas Souza BS. Genomic Evidence of SARS-CoV-2 Reinfection Involving E484K Spike Mutation, Brazil. Emerg Infect Dis 2021 May;27(5):1522-1524. Epub 2021 Feb 19. PMID: 33605869; PMCID: PMC8084516.

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