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Vanderson Rocha

Vanderson Rocha

Pesquisa

Nosso grupo, em colaboração com o Serviço de Hematologia e Terapia Celular da Universidade de São Paulo, investiga o papel das terapias celulares no tratamento de doenças hematológicas, incluindo resultados clínicos do transplantes autólogos e alogênicos de células-tronco hematopoiéticas (TCTH). Também estamos começando a investigar terapias usando células geneticamente modificadas (células CAR-T) para tratar doenças hematológicas como leucemias, linfomas e mieloma múltiplo, e células-tronco hematopoiéticas modificadas geneticamente para tratar a doença falciforme. Nosso objetivo é realizar estudos pré-clínicos “in vitro” e “in vivo” para validar a entrega de genes com vetores virais e não virais em linfócitos, NK e macrófagos. Também estamos interessados ​​em estabelecer um registro com doenças hematológicas raras como amiloidoses, macroglobulinemia de Waldenström, doença de Erdheim-Chester, síndrome de POEMS, doença de Castelman, etc.

Palavras-chave: TCTH autólogo e alogênico, terapia com células CAR-T, Linfomas, Leucemias, Mieloma Múltiplo

PESQUISA

Professor titular de Hematologia da Universidade de São Paulo e da Universidade de Oxford

Mestre e Doutor em Biotecnologia Terapêutica, Universidade de Paris

Graduação em Medicina pela Universidade Federal de Minas Gerais

ÁREAS DE PESQUISA

INFORMAÇÕES ADICIONAIS

Publicações Selecionadas

Silveira DRA, Quek L, Santos IS, Corby A, Coelho-Silva JL, Pereira-Martins DA, Vallance G, Brown B, Nardinelli L, Silva WF, Velloso EDRP, Lucena-Araujo AR, Traina F, Peniket A, Vyas P, Rego EM, Bendit I, Rocha V. Integrating clinical features with genetic factors enhances survival prediction for adults with acute myeloid leukemia. Blood Adv. 2020 May 26;4(10):2339-2350. PMID: 32453839

Balassa K, Rocha V. Anticancer cellular immunotherapies derived from umbilical cord blood. Expert Opin Biol Ther. 2018 Feb;18(2):121-134. Epub 2017 Nov 9.PMID: 29103317 Review./span>

Buss LF, Prete CA Jr, Abrahim CMM, Mendrone A Jr, Salomon T, de Almeida-Neto C, França RFO, Belotti MC, Carvalho MPSS, Costa AG, Crispim MAE, Ferreira SC, Fraiji NA, Gurzenda S, Whittaker C, Kamaura LT, Takecian PL, da Silva Peixoto P, Oikawa MK, Nishiya AS, Rocha V, Salles NA, de Souza Santos AA, da Silva MA, Custer B, Parag KV, Barral-Netto M, Kraemer MUG, Pereira RHM, Pybus OG, Busch MP, Castro MC, Dye C, Nascimento VH, Faria NR, Sabino EC. Three-quarters attack rate of SARS-CoV-2 in the Brazilian Amazon during a largely unmitigated epidemic. Science. 2021 Jan 15;371(6526):288-292. Epub 2020 Dec 8

Fatobene G, Rocha V, St Martin A, Hamadani M, Robinson S, Bashey A, Boumendil A, Brunstein C, Castagna L, Dominietto A, Finel H, Chalandon Y, Kenzey C, Kharfan-Dabaja M, Labussière-Wallet H, Moraleda JM, Pastano R, Perales MA, El Ayoubi HR, Ruggeri A, Sureda A, Volt F, Yakoub-Agha I, Zhang MJ, Gluckman E, Montoto S, Eapen M. Nonmyeloablative Alternative Donor Transplantation for Hodgkin and Non-Hodgkin Lymphoma: From the LWP-EBMT, Eurocord, and CIBMTR. J Clin Oncol. 2020 May 10;38(14):1518-1526

Fatobene G, Volt F, Moreira F, Mariano L, Chevallier P, Furst S, Labussière-Wallet H, de la Tour RP, Deconinck E, Cluzeau T, Russell N, Karakasis D, Forcade E, Ruggeri A, Gluckman E, Rocha V. Optimizing selection of double cord blood units for transplantation of adult patients with malignant diseases. Blood Adv. 2020 Dec 22;4(24):6327-6335.

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