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A área de Hepatologia da Rede D’Or foi criada a partir da demanda por protocolos bem fundamentados para o atendimento aos pacientes com doenças hepáticas e levou ao desenvolvimento desta área de pesquisa no IDOR. Entre os temas explorados  estão a doença hepática gordurosa não alcoólica, que está associada a maus hábitos alimentares, à diabetes e à obesidade. Embora seja, em grande parte dos casos, assintomática, a doença pode levar à cirrose e à insuficiência do fígado. Por isso, cientistas do IDOR procuram formas de realizar o diagnóstico precoce do problema e evitar a evolução para casos mais graves.

Outra linha de pesquisa importante nesta área é o estudo da hepatotoxicidade, isto é, do efeito que o uso de diferentes substâncias – especialmente ervas e medicamentos – pode ter sobre a saúde do fígado. Atualmente, os materiais disponíveis para consulta sobre o tema são aqueles desenvolvidos fora do Brasil, o que limita muito o entendimento dos casos locais. Por isso, a equipe do IDOR trabalha para levantar dados e gerar conhecimento sobre a hepatotoxicidade no contexto nacional, de forma a poder contribuir para uma melhora da saúde de nossa população. Os resultados poderão embasar a tomada de decisão das equipes médicas da RDSL e de outros serviços de saúde.

A equipe de hepatologia está envolvida, também, em ensaios clínicos com novas drogas para doenças como a hepatite B e em projetos de pesquisa sobre hepatite C e tumores de fígado.

Pesquisadores
Notícias Relacionadas
Principais Publicações

Yurdaydin C, Abbas Z, Buti M, Cornberg M, Esteban R, Etzion O, Gane EJ, Gish RG, Glenn JS, Hamid S, Heller T, Koh C, Lampertico P, Lurie Y, Manns M, Parana R, Rizzetto M, Urban S, Wedemeyer H; Hepatitis Delta International Network (HDIN). Treating chronic hepatitis delta: The need for surrogate markers of treatment efficacy. J Hepatol. 2019 May;70(5):1008-1015. Epub 2018 Dec 27. PMID: 30982526.

Paraná, R.; Schinoni, M. I. ; Campos, M. S. . Hepatitis D fluminante. In: Martín Tagle Arróspide. (Org.). APRENDIZAJE BASEADO EN CASOS CLÍNICOS – HEPATOLOGÍA 2021. 1a.ed.Lima: Academia Nacional de Medicina, 2021, v. , p. 87-97.

Bessone F, Hernandez N, Tagle M, Arrese M, Parana R, Méndez-Sánchez N, Ridruejo E, Mendizabal M, Dagher L, Contreras F, Fassio E, Pessoa M, Brahm J, Silva M. Drug-induced liver injury: A management position paper from the Latin American Association for Study of the liver. Ann Hepatol. 2021 Sep-Oct;24:100321. Epub 2021 Feb 17. PMID: 33609753.

Bessone F, García-Cortés M, Medina-Caliz I, Hernandez N, Parana R, Mendizabal M, Schinoni MI, Ridruejo E, Nunes V, Peralta M, Santos G, Anders M, Chiodi D, Tagle M, Montes P, Carrera E, Arrese M, Lizarzabal MI, Alvarez-Alvarez I, Caballano-Infantes E, Niu H, Pinazo J, Cabello MR, Lucena MI, Andrade RJ. Herbal and Dietary Supplements-Induced Liver Injury in Latin America: Experience From the LATINDILI Network. Clin Gastroenterol Hepatol. 2022 Mar;20(3):e548-e563. Epub 2021 Jan 9. PMID: 33434654.

García-Cortés M, Ortega-Alonso A, Matilla-Cabello G, Medina-Cáliz I, Castiella A, Conde I, Bonilla-Toyos E, Pinazo-Bandera J, Hernández N, Tagle M, Nunes V, Parana R, Bessone F, Kaplowitz N, Lucena MI, Alvarez-Alvarez I, Robles-Díaz M, Andrade RJ. Clinical presentation, causative drugs and outcome of patients with autoimmune features in two prospective DILI registries. Liver Int. 2023 Aug;43(8):1749-1760. Epub 2023 Jun 3. PMID: 37269163.

Pittella A, Atta E, Gomes L, Silva CC, & Pimenta AA. Insights on Treating HCV-Related B Cell Non-Hodgkin Lymphoma. Clinical Lymphoma, Myeloma and Leukemia, 16, S112-S113, 2016.

Costa VD, Pellegrini P, Rotman V, Pittella AM, Nunes EP, Lago BV, Lampe E, Mello FCA. Resistance Mutations A30K and Y93N Associated with Treatment Failure with Sofosbuvir and Daclatasvir for Hepatitis C Virus Infection Non-Responder Patients: Case Reports. Viruses. 2019 Oct 31;11(11):1004. PMID: 31683616; PMCID: PMC6893792.

Parente DB, Paiva FF, Oliveira Neto JA, Machado-Silva L, Figueiredo FA, Lanzoni V, Campos CF, do Brasil PE, Gomes Mde B, Perez Rde M, Rodrigues RS. Intravoxel Incoherent Motion Diffusion Weighted MR Imaging at 3.0 T: Assessment of Steatohepatitis and Fibrosis Compared with Liver Biopsy in Type 2 Diabetic Patients. PLoS One. 2015 May 11;10(5):e0125653. PMID: 25961735; PMCID: PMC4427182.

Parente DB, Oliveira Neto JA, Brasil PEAA, Paiva FF, Ravani JPR, Gomes MB, Lanzoni V, Campos CFF, Machado-Silva L, Perez RM, Rodrigues RS. Preperitoneal fat as a non-invasive marker of increased risk of severe non-alcoholic fatty liver disease in patients with type 2 diabetes. J Gastroenterol Hepatol. 2018 Feb;33(2):511-517. PMID: 28726335.

Parente DB, Perazzo H, Paiva FF, Campos CFF, Saboya CJ, Pereira SE, Silva FDE, Rodrigues RS, Perez RM. Higher cut-off values of non-invasive methods might be needed to detect moderate-to-severe steatosis in morbid obese patients: a pilot study. Sci Rep. 2020 Sep 14;10(1):15007. PMID: 32929103; PMCID: PMC7490697.

Amorim VB, Parente DB, Paiva FF, Oliveira Neto JA, Miranda AA, Moreira CC, Fernandes FF, Campos CFF, Leite NC, Perez RM, Rodrigues RS. Can gadoxetic acid-enhanced magnetic resonance imaging be used to avoid liver biopsy in patients with nonalcoholic fatty liver disease? World J Hepatol. 2020 Sep 27;12(9):661-671. PMID: 33033571; PMCID: PMC7522564.

Eiras-Araújo AL, Parente DB, da Silva AC, da Motta Rezende GF, Mendes GB, Luiz RR, de Oliveira Souza R, da Costa Generalis S, Rodrigues RS, Perez RM. Relative enhancement index can be used to quantify liver function in cirrhotic patients that undergo gadoxetic acid-enhanced MRI. Eur Radiol. 2023 Jan 18. Epub ahead of print. PMID: 36651953.

Queiroz-Telles F, de Hoog S, Santos DW, Salgado CG, Vicente VA, Bonifaz A, Roilides E, Xi L, Azevedo CM, da Silva MB, Pana ZD, Colombo AL, Walsh TJ. Chromoblastomycosis. Clin Microbiol Rev. 2017 Jan;30(1):233-276.

Parente DB, Rodrigues RS, Paiva FF, Oliveira Neto JA, Machado-Silva L, Lanzoni V, Campos CF, Eiras-Araujo AL, do Brasil PE, Garteiser P, Gomes MB, de Mello Perez R. Is MR spectroscopy really the best MR-based method for the evaluation of fatty liver in diabetic patients in clinical practice? PLoS One. 2014 Nov 26;9(11):e112574.

Perazzo H, Fernandes FF, Castro Filho EC, Perez RM. Points to be considered when using transient elastography for diagnosis of portal hypertension according to the Baveno’s VI consensus. J Hepatol. 2015 Oct;63(4):1048-9.

Amorim VB, Parente DB, Paiva FF, Oliveira Neto JA, Miranda AA, Moreira CC, Fernandes FF, Campos CFF, Leite NC, Perez RM, Rodrigues RS. Can gadoxetic acid-enhanced magnetic resonance imaging be used to avoid liver biopsy in patients with nonalcoholic fatty liver disease? World J Hepatol. 2020 Sep 27;12(9):661-671.

Parente DB, Perazzo H, Paiva FF, Campos CFF, Saboya CJ, Pereira SE, Silva FDE, Rodrigues RS, Perez RM. Higher cut-off values of non-invasive methods might be needed to detect moderate-to-severe steatosis in morbid obese patients: a pilot study. Sci Rep. 2020 Sep 14;10(1):15007.

Pozzobon FM, Perazzo H, Bozza FA, Rodrigues RS, de Mello Perez R, Chindamo MC. Liver injury predicts overall mortality in severe COVID-19: a prospective multicenter study in Brazil. Hepatol Int. 2021 Apr;15(2):493-501.

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