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Infectologia/Vacinas

Infectologia/Vacinas

A vigilância epidemiológica é o principal objetivo desta área de pesquisa, que trabalha com o atendimento de pacientes com neuroinfecções e arboviroses como dengue, zika e chikungunya nos hospitais da RDSL. 

Durante a pandemia de covid-19, a equipe se dedicou quase exclusivamente à nova doença, participando de ensaios clínicos de vacinas e propostas terapêuticas (veja o quadro O IDOR na pandemia de covid-19).  Com a estrutura montada, o setor pretende seguir participando de novos ensaios clínicos para vacinas contra outras doenças.

Pesquisadores
Notícias Relacionadas
Principais Publicações

Pittella A, Atta E, Gomes L, Silva CC, & Pimenta AA. Insights on Treating HCV-Related B Cell Non-Hodgkin Lymphoma. Clinical Lymphoma, Myeloma and Leukemia, 16, S112-S113, 2016.

Costa VD, Pellegrini P, Rotman V, Pittella AM, Nunes EP, Lago BV, Lampe E, Mello FCA. Resistance Mutations A30K and Y93N Associated with Treatment Failure with Sofosbuvir and Daclatasvir for Hepatitis C Virus Infection Non-Responder Patients: Case Reports. Viruses. 2019 Oct 31;11(11):1004. PMID: 31683616; PMCID: PMC6893792.

Clemens SAC, Folegatti PM, Emary KRW, Weckx LY, Ratcliff J, Bibi S, De Almeida Mendes AV, Milan EP, Pittella A, Schwarzbold AV, Sprinz E, Aley PK, Bonsall D, Fraser C, Fuskova M, Gilbert SC, Jenkin D, Kelly S, Kerridge S, Lambe T, Marchevsky NG, Mujadidi YF, Plested E, Ramasamy MN, Simmonds P, Golubchik T, Voysey M, Pollard AJ; AMPHEUS Project; Oxford COVID Vaccine Trial Team. Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 lineages circulating in Brazil. Nat Commun. 2021 Oct 6;12(1):5861. PMID: 34615860; PMCID: PMC8494913.

Voysey M, Costa Clemens SA, Madhi SA, Weckx LY, Folegatti PM, Aley PK, Angus B, Baillie VL, Barnabas SL, Bhorat QE, Bibi S, Briner C, Cicconi P, Clutterbuck EA, Collins AM, Cutland CL, Darton TC, Dheda K, Dold C, Duncan CJA, Emary KRW, Ewer KJ, Flaxman A, Fairlie L, Faust SN, Feng S, Ferreira DM, Finn A, Galiza E, Goodman AL, Green CM, Green CA, Greenland M, Hill C, Hill HC, Hirsch I, Izu A, Jenkin D, Joe CCD, Kerridge S, Koen A, Kwatra G, Lazarus R, Libri V, Lillie PJ, Marchevsky NG, Marshall RP, Mendes AVA, Milan EP, Minassian AM, McGregor A, Mujadidi YF, Nana A, Padayachee SD, Phillips DJ, Pittella A, et al., and Oxford COVID Vaccine Trial Group. Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials. Lancet. 2021 Mar 6;397(10277):881-891. Epub 2021 Feb 19. Erratum in: Lancet. 2021 Mar 6;397(10277):880. PMID: 33617777; PMCID: PMC7894131.

Voysey M, Clemens SAC, Madhi SA, Weckx LY, Folegatti PM, Aley PK, Angus B, Baillie VL, Barnabas SL, Bhorat QE, Bibi S, Briner C, Cicconi P, Collins AM, Colin-Jones R, Cutland CL, Darton TC, Dheda K, Duncan CJA, Emary KRW, Ewer KJ, Fairlie L, Faust SN, Feng S, Ferreira DM, Finn A, Goodman AL, Green CM, Green CA, Heath PT, Hill C, Hill H, Hirsch I, Hodgson SHC, Izu A, Jackson S, Jenkin D, Joe CCD, Kerridge S, Koen A, Kwatra G, Lazarus R, Lawrie AM, Lelliott A, Libri V, Lillie PJ, Mallory R, Mendes AVA, Milan EP, Minassian AM, McGregor A, Morrison H, Mujadidi YF, Nana A, O’Reilly PJ, Padayachee SD, Pittella A, et al., and Oxford COVID Vaccine Trial Group. Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK. Lancet. 2021 Jan 9;397(10269):99-111. Epub 2020 Dec 8. Erratum in: Lancet. 2021 Jan 9;397(10269):98. PMID: 33306989; PMCID: PMC7723445.

Viana LA, Cristelli MP, Santos DW, Tavares MG, Dantas MTC, Felipe CR, Silva HT, Pestana JM. Influence of epidemiology, immunosuppressive regimens, clinical presentation, and treatment on kidney transplant outcomes of patients diagnosed with tuberculosis: A retrospective cohort analysis. Am J Transplant. 2019 May;19(5):1421-1431.

Queiroz-Telles F, de Hoog S, Santos DW, Salgado CG, Vicente VA, Bonifaz A, Roilides E, Xi L, Azevedo CM, da Silva MB, Pana ZD, Colombo AL, Walsh TJ. Chromoblastomycosis. Clin Microbiol Rev. 2017 Jan;30(1):233-276.

Santos DW, Camargo LF, Gonçalves SS, Ogawa MM, Tomimori J, Enokihara MM, Medina-Pestana JO, Colombo AL. Melanized fungal infections in kidney transplant recipients: contributions to optimize clinical management. Clin Microbiol Infect. 2017 May;23(5):333.e9-333.e14. Epub 2017 Jan 3. PMID: 28062320.

Santos DWCL, Hagen F, Meis JF, Cristelli MP, Viana LA, Bernardi FDC, Tedesco-Silva H, Medina-Pestana JO, Colombo AL. Donor-Derived Transmission of Cryptococcus gattii sensu lato in Kidney Transplant Recipients. Emerg Infect Dis. 2020 Jun;26(6):1329-1331. PMID: 32441623; PMCID: PMC7258454.

Santos DWCL, de Azevedo CMPES, Vicente VA, Queiroz-Telles F, Rodrigues AM, de Hoog GS, Denning DW, Colombo AL. The global burden of chromoblastomycosis. PLoS Negl Trop Dis. 2021 Aug 12;15(8):e0009611. PMID: 34383752; PMCID: PMC8360387.

Cerbino Neto J, Werneck GL, Costa CH. Factors associated with the incidence of urban visceral leishmaniasis: an ecological study in Teresina, Piauí State, Brazil. Cad Saude Pública. 2009 Jul;25(7):1543-51. PMID: 19578575.

Metsky HC, Matranga CB, Wohl S, Schaffner SF, Freije CA, Winnicki SM, West K, Qu J, Baniecki ML, Gladden-Young A, Lin AE, Tomkins-Tinch CH, Ye SH, Park DJ, Luo CY, Barnes KG, Shah RR, Chak B, Barbosa-Lima G, Delatorre E, Vieira YR, Paul LM, Tan AL, Barcellona CM, Porcelli MC, Vasquez C, Cannons AC, Cone MR, Hogan KN, Kopp EW, Anzinger JJ, Garcia KF, Parham LA, Ramírez RMG, Montoya MCM, Rojas DP, Brown CM, Hennigan S, Sabina B, Scotland S, Gangavarapu K, Grubaugh ND, Oliveira G, Robles-Sikisaka R, Rambaut A, Gehrke L, Smole S, Halloran ME, Villar L, Mattar S, Lorenzana I, Cerbino-Neto J, et al. Zika virus evolution and spread in the Americas. Nature. 2017 Jun 15;546(7658):411-415. Epub 2017 May 24. PMID: 28538734; PMCID: PMC5563848.

Cerbino-Neto J, Mesquita EC, Souza TM, Parreira V, Wittlin BB, Durovni B, Lemos MC, Vizzoni A, Bispo de Filippis AM, Sampaio SA, Gonçalves Bde S, Bozza FA. Clinical Manifestations of Zika Virus Infection, Rio de Janeiro, Brazil, 2015. Emerg Infect Dis. 2016 Jul;22(7):1318-20. Epub 2016 Jul 15. PMID: 27070847; PMCID: PMC4918188.

Bravo L, Smolenov I, Han HH, Li P, Hosain R, Rockhold F, Clemens SAC, Roa C Jr, Borja-Tabora C, Quinsaat A, Lopez P, López-Medina E, Brochado L, Hernández EA, Reynales H, Medina T, Velasquez H, Toloza LB, Rodriguez EJ, de Salazar DIM, Rodríguez CA, Sprinz E, Cerbino-Neto J, et al. Efficacy of the adjuvanted subunit protein COVID-19 vaccine, SCB-2019: a phase 2 and 3 multicentre, double-blind, randomised, placebo-controlled trial. Lancet. 2022 Jan 29;399(10323):461-472. Epub 2022 Jan 20. PMID: 35065705; PMCID: PMC8776284.

Cerbino-Neto J, Peres IT, Varela MC, Brandão LGP, de Matos JA, Pinto LF, da Costa MD, Garcia MHO, Soranz D, Maia MLS, Krieger MA, da Cunha RV, Camacho LAB, Ranzani O, Hamacher S, Bozza FA, Penna GO. Seroepidemiology of SARS-CoV-2 on a partially vaccinated island in Brazil: Determinants of infection and vaccine response. Front Public Health. 2022 Nov 14;10:1017337. PMID: 36457326; PMCID: PMC9706255.

Nobrega de Almeida J, Francisco EC, Holguín Ruiz A, Cuéllar LE, Rodrigues Aquino V, Verena Mendes A, Queiroz-Telles F, Santos DW, Guimarães T, Maranhão Chaves G, Grassi de Miranda B, Araújo Motta F, Vargas Schwarzbold A, Oliveira M, Riera F, Sardi Perozin J, Pereira Neves R, França E Silva ILA, Sztajnbok J, Fernandes Ramos J, Borges Botura M, Carlesse F, de Tarso de O E Castro P, Nyirenda T, Colombo AL. Epidemiology, clinical aspects, outcomes and prognostic factors associated with Trichosporon fungaemia: results of an international multicentre study carried out at 23 medical centres. J Antimicrob Chemother. 2021 Jun 18;76(7):1907-1915. PMID: 33890055.

Merryn Voysey, Sue Ann Costa Clemens, Shabir A Madhi, Lily Y Weckx, Pedro M Folegatti, Parvinder K Aley, Brian Angus, Vicky L Baillie, Shaun L Barnabas, Qasim E Bhorat, Sagida Bibi, Carmen Briner, Paola Cicconi, Andrea M Collins, Rachel Colin-Jones, Clare L Cutland, Thomas C Darton, Keertan Dheda, Christopher J A Duncan, Katherine R W Emary, Katie J Ewer, Lee Fairlie, Saul N Faust, Shuo Feng, Daniela M Ferreira, Adam Finn, Anna L Goodman, Catherine M Green, Christopher A Green, Paul T Heath, Catherine Hill, Helen Hill, Ian Hirsch, Susanne H C Hodgson, Alane Izu, Susan Jackson, Daniel Jenkin, Carina C D Joe, Simon Kerridge, Anthonet Koen, Gaurav Kwatra, Rajeka Lazarus, Alison M Lawrie, Alice Lelliott, Vincenzo Libri, Patrick J Lillie, Raburn Mallory, Ana V A Mendes, et al., Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK. The Lancet. Volume 397, Issue 10269, 2021, Pages 99-111, ISSN 0140-6736.

Silveira MAD, de Souza SP, Dos Santos Galvão EB, Teixeira MB, Gomes MMD, Damiani LP, Bahiense BA, Cabral JB, De Oliveira CWLM, Mascarenhas TR, Pinheiro PCG, Alves MS, de Melo RMV, Berretta AA, Leite FM, Nonaka CKV, de Freitas Souza BS, Mendes AVA, da Guarda SF, da Hora Passos R. The use of standardized Brazilian green propolis extract (EPP-AF) as an adjunct treatment for hospitalized COVID-19 patients (BeeCovid2): a structured summary of a study protocol for a randomized controlled trial. Trials. 2022 Apr 4;23(1):255. PMID: 35379306; PMCID: PMC8978159.

Nonaka CKV, Gräf T, Barcia CAL, Costa VF, de Oliveira JL, Passos RDH, Bastos IN, de Santana MCB, Santos IM, de Sousa KAF, Weber TGL, Siqueira IC, Rocha CAG, Mendes AVA, Souza BSF. SARS-CoV-2 variant of concern P.1 (Gamma) infection in young and middle-aged patients admitted to the intensive care units of a single hospital in Salvador, Northeast Brazil, February 2021. Int J Infect Dis. 2021 Oct;111:47-54. Epub 2021 Aug 11. PMID: 34390857; PMCID: PMC8356754.

Clemens SAC, Folegatti PM, Emary KRW, Weckx LY, Ratcliff J, Bibi S, De Almeida Mendes AV, Milan EP, Pittella A, Schwarzbold AV, Sprinz E, Aley PK, Bonsall D, Fraser C, Fuskova M, Gilbert SC, Jenkin D, Kelly S, Kerridge S, Lambe T, Marchevsky NG, Mujadidi YF, Plested E, Ramasamy MN, Simmonds P, Golubchik T, Voysey M, Pollard AJ; AMPHEUS Project; Oxford COVID Vaccine Trial Team. Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 lineages circulating in Brazil. Nat Commun. 2021 Oct 6;12(1):5861. PMID: 34615860; PMCID: PMC8494913.

Kunikazu Yamane, Flávia Rossi, Maria Goreth M. A. Barberino, Jennifer M. Adams-Haduch2, Yohei Doi and David L. Paterson. 16S ribosomal RNA methylase RmtD produced by Klebsiella pneumoniae in Brazil. Journal of Antimicrobial Chemotherapy (2008) 61, 746–760

Maria Goreth Barberino, Marcio de Oliveira Silva, Ana Carolina Palmeiras Arraes, Luís Cláudio Correia, Ana Verena Mendes. Direct identification from positive blood broth culture by matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF MS). Brazilian Journal of Infectious Diseases 2017;2 1(3):339–342

E.C. Francisco, J.N. de Almeida Junior, F. de Queiroz Telles, V.R. Aquino, A.V.A. Mendes, M.G.M. de Andrade Barberino, P. de Tarso O. Castro, T. Guimarães,R.C. Hahn, A.C.B. Padovan, G.M. Chaves, A.L. Colombo. Species distribution and antifungal susceptibility of 358 Trichosporon clinical isolates collected in 24 medical centres. Clinical Microbiology and Infection. 25.7 (2019): 909-e1.

Helena Ferreira Leal, Jailton Azevedo, Giulyana Evelyn Oliveira Silva, Angelica Maria Lima Amorim, Larissa Rangel Cabral de Roma, Ana Carolina Palmeira Arraes, Edilane Lins Gouveia, Mitermayer Galvão Reis, Ana Verena Mendes, Marcio de Oliveira Silva, Maria Goreth Barberino, Ianick Souto Martins and Joice Neves Reis.Bloodstream infections caused by Multidrug-resistant gram-negative bacteria: epidemiological, clinical and microbiological features. BMC Infectious Diseases, (2019) 19:609

Nobrega de Almeida Jr, J., Moreno, L., Francisco, E. C., Noronha Marques, G., Mendes, A. V., Barberino, M. G., & Colombo, A. L.. Trichosporon asahii superinfections in critically ill COVID‐19 patients overexposed to antimicrobials and corticosteroids. Mycoses, (2021) 64(8), 817-822.

Evangelista, A.F.; Vannier-Santos, M.A.; de Assis Silva, G.S.; Silva, D. N.; Juiz, P. J. L.; Nonaka, C. K. V.; Santos, R.R; Soares, M.B.P Villarreal, C. F.Bone marrow-derived mesenchymal stem/stromal cells reverse the sensorial diabetic neuropathy via modulation of spinal neuroinflammatory cascades. J Neuroinflammation 15, 189 (2018).

Nonaka, C.K.V.; Sampaio, G.L.; de Aragão França, L.; Cavalcante, B.R.; Silva, K.N.; Khouri, R.; Torres, F.G.; Meira, C.S.; de Souza Santos, E.; Macedo, C.T.; Paredes, B.D.; Rocha, V.P.C.; Rogatto, S.R.; Ribeiro dos Santos, R.; Souza, B.S.d.F.; Soares, M.B.P. Therapeutic miR-21 Silencing Reduces Cardiac Fibrosis and Modulates Inflammatory Response in Chronic Chagas Disease. Int. J. Mol. Sci. 2021, 22, 3307.

Nonaka, C.K.V.; Macêdo, C.T.; Cavalcante, B.R.R.; Alcântara, A.C.d.; Silva, D.N.; Bezerra, M.d.R.; Caria, A.C.I.; Tavora, F.R.F.; Neto, J.D.d.S.; Noya-Rabelo, M.M.; Rogatto, S.R.; Ribeiro dos Santos, R.; Souza, B.S.d.F.; Soares, M.B.P. Circulating miRNAs as Potential Biomarkers Associated with Cardiac Remodeling and Fibrosis in Chagas Disease Cardiomyopathy. Int. J. Mol. Sci. 2019, 20, 4064.

Improta Caria, A.C.; Nonaka, C.K.V.; Pereira, C.S.; Soares, M.B.P.; Macambira, S.G.; Souza, B.S.d.F. Exercise Training-Induced Changes in MicroRNAs: Beneficial Regulatory Effects in Hypertension, Type 2 Diabetes, and Obesity. Int. J. Mol. Sci. 2018, 19, 3608.

Nonaka CKV, Franco MM, Gräf T, de Lorenzo Barcia CA, de Ávila Mendonça RN, de Sousa KAF, Neiva LMC, Fosenca V, Mendes AVA, de Aguiar RS, Giovanetti M, de Freitas Souza BS. Genomic Evidence of SARS-CoV-2 Reinfection Involving E484K Spike Mutation, Brazil. Emerg Infect Dis. 2021 May;27(5):1522-1524. Epub 2021 Feb 19. PMID: 33605869; PMCID: PMC8084516.

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