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A equipe de pesquisa em cardiologia acompanha a implementação de protocolos de atendimento em cardiologia na RDSL e explora os dados obtidos nestes atendimentos, em particular nos casos de fibrilação atrial, insuficiência cardíaca, dor torácica e síncope que chegam às salas de emergência dos hospitais RDSL em todo o Brasil. Também desenvolve projetos sobre amiloidoses, grupo de doenças raras geradas pelo acúmulo de proteínas anormais em tecidos como o do coração, prejudicando sua função.

Além disso, os cientistas do IDOR desenvolvem pesquisas de ponta em imagem cardiovascular, com uso de tecnologias como ressonância magnética, PET-CT e SPECT-CT. As três técnicas são usadas, por exemplo, no acompanhamento de pacientes com complicações cardíacas da doença de Chagas. Neste projeto, os cientistas avaliam a presença de fibrose do miocárdio como fator prognóstico para pacientes que apresentam arritmias, além de observar o impacto da inflamação sobre a saúde cardiovascular dos pacientes.

Pacientes com manifestações cardiológicas da doença de Chagas, em especial a dor torácica associada a alterações de eletrocardiograma, podem ser erroneamente diagnosticados com síndrome coronária aguda. Por isso, a equipe de pesquisa em cardiologia também trabalha com novas modalidades de exames de imagem que permitam o diagnóstico mais preciso dessa condição.

Outros objetos de estudo do grupo são a fibrose cardíaca e o risco cardiovascular em pacientes com doença hepática gordurosa não alcoólica, a disfunção cardíaca gerada pelo uso de medicamentos quimioterápicos, o uso de novos dispositivos, como os desfibriladores implantáveis, e a análise genética de canalopatias – anormalidades genéticas que levam a um risco aumentado de arritmias e morte súbita. A equipe trabalha, ainda, no desenvolvimento de ensaios clínicos envolvendo novas drogas, patrocinados pela indústria farmacêutica.

Pesquisadores
Notícias Relacionadas
Principais Publicações

Moll-Bernardes R, Ferreira JR, Schaustz EB, Sousa AS, Mattos JD, Tortelly MB, Pimentel AL, Figueiredo ACBS, Noya-Rabelo MM, Fortier S, Matos E Silva FA, Vera N, Conde L, Cabral-Castro MJ, Albuquerque DC, Rosado-de-Castro PH, Camargo GC, Pinheiro MVT, Freitas DOL, Pittella AM, Araújo JAM, Marques AC, Gouvêa EP, Terzi FVO, Zukowski CN, Gismondi RAOC, Bandeira BS, Oliveira RS, Abufaiad BEJ, Miranda JSS, Miranda LG, Souza OF, Bozza FA, Luiz RR, Medei E. New Insights on the Mechanisms of Myocardial Injury in Hypertensive Patients With COVID-19. J Clin Immunol. 2023 Oct;43(7):1496-1505. doi: 10.1007/s10875-023-01523-6. Epub 2023 Jun 9. PMID: 37294518; PMCID: PMC10250847.

de Oliveira RS, Moll-Bernardes R, de Brito AX, Pinheiro MVT, de Almeida SA, da Silva Gomes NL, de Oliveira Terzi FV, Moreira OC, Xavier SS, Rosado-de-Castro PH, de Sousa AS. Use of PET/CT to detect myocardial inflammation and the risk of malignant arrhythmia in chronic Chagas disease. J Nucl Cardiol. 2023 Dec;30(6):2702-2711. doi: 10.1007/s12350-023-03350-z. Epub 2023 Aug 21. PMID: 37605061.

Moll-Bernardes R, Ferreira JR, Sousa AS, Tortelly MB, Pimentel AL, Figueiredo ACBS, Schaustz EB, Secco JCP, Sales ARK, Terzi FVO, Xavier de Brito A, Sarmento RO, Noya-Rabelo MM, Fortier S, Matos E Silva FA, Vera N, Conde L, Cabral-Castro MJ, Albuquerque DC, Rosado de-Castro P, Camargo GC, Pinheiro MVT, Souza OF, Bozza FA, Luiz RR, Medei E. Impact of the immune profiles of hypertensive patients with and without obesity on COVID-19 severity. Int J Obes (Lond). 2023 Nov 6. doi: 10.1038/s41366-023-01407-0. Epub ahead of print. PMID: 37932408.

de Brito ASX, Moll-Bernardes RJ, Pinheiro MVT, Camargo GC, Siqueira FPR, Oliveira RS, Glavam AP, de Almeida SA, de Holanda MT, Sangenis LHC, Mendes FSNS, Rosado-de-Castro PH, de Sousa AS. Autonomic denervation, myocardial hypoperfusion and fibrosis may predict ventricular arrhythmia in the early stages of Chagas cardiomyopathy. J Nucl Cardiol. 2023 Dec;30(6):2379-2388. doi: 10.1007/s12350-023-03281-9. Epub 2023 May 24. PMID: 37226005.

Terzi FVO, Camargo GC, Parente DB, Pittella AM, Silva-Junior G, de Novaes GG, Oliveira Neto JA, Barroso JM, Pinheiro MVT, Xavier de Brito AS, de Oliveira RS, Rodrigues RS, de Mello Perez R, de Sousa AS, Moll-Bernardes RJ. How Cardiac Fibrosis Assessed via T1 Mapping Is Associated with Liver Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease. J Clin Med. 2023 Nov 29;12(23):7381. doi: 10.3390/jcm12237381. PMID: 38068433; PMCID: PMC10707357.

Lopes RD, Macedo AVS, de Barros E Silva PGM, Moll-Bernardes RJ, Feldman A, D’Andréa Saba Arruda G, de Souza AS, de Albuquerque DC, Mazza L, Santos MF, Salvador NZ, Gibson CM, Granger CB, Alexander JH, de Souza OF; BRACE CORONA investigators. Continuing versus suspending angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: Impact on adverse outcomes in hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–The BRACE CORONA Trial. Am Heart J. 2020 Aug;226:49-59. Epub 2020 May 13. PMID: 32502882; PMCID: PMC7219415.

Esteves V, Zukowski CN, Luca FA de, Sousa IB dos S, Bandeira BS, Camiletti A, Arruda, G, Feldman, A, & Souza, OF de. The Association between Covid-19 and ST Elevation Myocardial Infarction: Variable Clinical Presentations on a Case Report Series. Int J Cardiovasc Sci [Internet]. 2020Jul;33(4):429–35.

Lopes RD, Macedo AVS, de Barros E Silva PGM, Moll-Bernardes RJ, Dos Santos TM, Mazza L, Feldman A, D’Andréa Saba Arruda G, de Albuquerque DC, Camiletti AS, de Sousa AS, de Paula TC, Giusti KGD, Domiciano RAM, Noya-Rabelo MM, Hamilton AM, Loures VA, Dionísio RM, Furquim TAB, De Luca FA, Dos Santos Sousa ÍB, Bandeira BS, Zukowski CN, de Oliveira RGG, Ribeiro NB, de Moraes JL, Petriz JLF, Pimentel AM, Miranda JS, de Jesus Abufaiad BE, Gibson CM, Granger CB, Alexander JH, de Souza OF; BRACE CORONA Investigators. Effect of Discontinuing vs Continuing Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers on Days Alive and Out of the Hospital in Patients Admitted With COVID-19: A Randomized Clinical Trial. JAMA. 2021 Jan 19;325(3):254-264. PMID: 33464336; PMCID: PMC7816106.

Luca, FAD, Arruda, G, Esteves, V, Feldman, A, Sousa, BS, Brandão, JCV, Garcia, RM, & Souza, OF (2021). Pulmonary Embolism in Patients with Covid-19 in Direct Oral Anticoagulant. Int J Cardiovasc Sci, 35(1), 140-144.

Moll-Bernardes R, Fortier SC, Sousa AS, Lopes RD, Vera N, Conde L, Feldman A, Arruda G, Cabral-Castro M, Albuquerque DC, Paula TC, Furquim T, Loures VA, Giusti K, Oliveira N, Macedo A, Barros E Silva P, De Luca F, Kotsugai M, Domiciano R, Silva FA, Santos MF, Souza OF, Bozza FA, Luiz RR, Medei E. NKG2A Expression among CD8 Cells Is Associated with COVID-19 Progression in Hypertensive Patients: Insights from the BRACE CORONA Randomized Trial. J Clin Med. 2022 Jun 27;11(13):3713. PMID: 35806995; PMCID: PMC9267446.

Scanavini-Filho MA, Berwanger O, Matthias W, Aguiar MO, Chiang HP, Azevedo L, Baracioli LM, Lima FG, Furtado RHM, Dalcoquio TF, Menezes FR, Ferrari AG, de Luca F, Giugliano RP, Goodman S, Nicolau JC. Effects of Ticagrelor and Clopidogrel on Coronary Microcirculation in Patients with Acute Myocardial Infarction. Adv Ther. 2022 Apr;39(4):1832-1843. Epub 2022 Feb 26. PMID: 35218519; PMCID: PMC8989815.

Lopes RD, Macedo AVS, de Barros E Silva PGM, Moll-Bernardes RJ, Dos Santos TM, Mazza L, Feldman A, D’Andréa Saba Arruda G, de Albuquerque DC, Camiletti AS, de Sousa AS, de Paula TC, Giusti KGD, Domiciano RAM, Noya-Rabelo MM, Hamilton AM, Loures VA, Dionísio RM, Furquim TAB, De Luca FA, et al.; BRACE CORONA Investigators. Effect of Discontinuing vs Continuing Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers on Days Alive and Out of the Hospital in Patients Admitted With COVID-19: A Randomized Clinical Trial. JAMA. 2021 Jan 19;325(3):254-264. PMID: 33464336; PMCID: PMC7816106.

De Luca FA, Garrido AG, Prist R, Gutierrez PS, Rocha-e-Silva M, Cruz RJ Jr. Short-term effects of hydroxyethylstarch resuscitation on systemic and regional hemodynamics and metabolism in a brain-dead canine model. J Surg Res. 2011 Jul;169(1):132-8. Epub 2009 Dec 21. PMID: 20338587.

De Luca FA, Cruz RJ Jr, Garrido Adel P, Prist R, Rocha-E-Silva M. Initial hepatosplanchnic blood flow distribution and oxygen metabolism in experimental model of hypotensive brain death. Ann Transplant. 2009 Jan-Mar;14(1):38-46. PMID: 19289995.

Berwanger O, Nicolau JC, Carvalho AC, Jiang L, Goodman SG, Nicholls SJ, Parkhomenko A, Averkov O, Tajer C, Malaga G, Saraiva JFK, Fonseca FA, De Luca FA, et al. Ticagrelor vs Clopidogrel After Fibrinolytic Therapy in Patients With ST-Elevation Myocardial Infarction: A Randomized Clinical Trial. JAMA Cardiol. 2018 May 1;3(5):391-399. Erratum in: JAMA Cardiol. 2018 May 1;3(5):445. PMID: 29525822; PMCID: PMC5875327.

Regueiro A, Linke A, Latib A, Ihlemann N, Urena M, Walther T, Husser O, Herrmann HC, Nombela-Franco L, Cheema AN, Le Breton H, Stortecky S, Kapadia S, Bartorelli AL, Sinning JM, Amat-Santos I, Munoz-Garcia A, Lerakis S, Gutiérrez-Ibanes E, Abdel-Wahab M, Tchetche D, Testa L, Eltchaninoff H, Livi U, Castillo JC, Jilaihawi H, Webb JG, Barbanti M, Kodali S, de Brito FS Jr, Ribeiro HB, Miceli A, Fiorina C, Dato GM, Rosato F, Serra V, Masson JB, Wijeysundera HC, Mangione JA, Ferreira MC, Lima VC, Carvalho LA, Abizaid A, Marino MA, Esteves V, et al. Association Between Transcatheter Aortic Valve Replacement and Subsequent Infective Endocarditis and In-Hospital Death. JAMA. 2016 Sep 13;316(10):1083-92. PMID: 27623462.

Esteves, V. & Tchetche, D. Transcatheter aortic valve replacement for bicuspid valves–from anatomy all the way to the treatment. J Transcat Intervent, 28, eA202013. 2020.

Del Val D, Abdel-Wahab M, Mangner N, Durand E, Ihlemann N, Urena M, Pellegrini C, Giannini F, Gasior T, Wojakowski W, Landt M, Auffret V, Sinning JM, Cheema AN, Nombela-Franco L, Chamandi C, Campelo-Parada F, Munoz-Garcia E, Herrmann HC, Testa L, Won-Keun K, Castillo JC, Alperi A, Tchetche D, Bartorelli AL, Kapadia S, Stortecky S, Amat-Santos I, Wijeysundera HC, Lisko J, Gutiérrez-Ibanes E, Serra V, Salido L, Alkhodair A, Livi U, Chakravarty T, Lerakis S, Vilalta V, Regueiro A, Romaguera R, Kappert U, Barbanti M, Masson JB, Maes F, Fiorina C, Miceli A, Kodali S, Ribeiro HB, Mangione JA, Sandoli de Brito F Jr, Actis Dato GM, Rosato F, Ferreira MC, Correia de Lima V, Colafranceschi AS, Abizaid A, Marino MA, Esteves V, et al. Stroke Complicating Infective Endocarditis After Transcatheter Aortic Valve Replacement. J Am Coll Cardiol. 2021 May 11;77(18):2276-2287. PMID: 33958124.

Del Val D, Linke A, Abdel-Wahab M, Latib A, Ihlemann N, Urena M, Won-Keun K, Husser O, Herrmann HC, Nombela-Franco L, Cheema AN, Le Breton H, Stortecky S, Bartorelli AL, Sinning JM, Amat-Santos I, Munoz-Garcia A, Lerakis S, Gutiérrez-Ibanez E, Landt M, Tchetche D, Testa L, Eltchaninoff H, Livi U, Castillo JC, Chakravarty T, Webb JG, Barbanti M, Kodali S, de Brito FS Jr, Ribeiro HB, Miceli A, Fiorina C, Dato GMA, Rosato F, Serra V, Masson JB, Wijeysundera HC, Mangione JA, Ferreira MC, Lima VC, Colafranceschi AS, Abizaid A, Marino MA, Esteves V, et al. Long-Term Outcomes After Infective Endocarditis After Transcatheter Aortic Valve Replacement. Circulation. 2020 Oct 13;142(15):1497-1499. Epub 2020 Oct 12. PMID: 33044863.

Esteves V, Oliveira MAP, Feitosa FS, Mariani J Jr, Campos CM, Hajjar LA, Lisboa LA, Jatene FB, Filho RK, Lemos Neto PA. Late clinical outcomes of myocardial hybrid revascularization versus coronary artery bypass grafting for complex triple-vessel disease: Long-term follow-up of the randomized MERGING clinical trial. Catheter Cardiovasc Interv. 2021 Feb 1;97(2):259-264. Epub 2020 Jan 10. PMID: 31922359.

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A Avezum, AC Mattos, GBDF.Oliveira, IM Pinto, CC Magalhães, JFM Ferreira, ACP Chagas, M Wajngarten, AR Rombaldi, P Cicogna Neto, JI Bocchese, EG Barragan, TDO Silva, F Savioli Neto, JFK Saraiva. Prevalence of Blood Pressure Control in a Registry of Clinical Practice – Preliminary Data From Pinnacle-Brazil Registry. Global Heart. Volume 13, Issue 4, 2018, Page 459, ISSN 2211-8160.

Silva TO, Darze ES, Ritt LEF, Almeida ALC, Ximenes A. Transthyretin Amyloidosis (ATTR) – The Role of Multimodality in the Definitive Diagnosis. Arq Bras Cardiol. 2020 Apr;114(4 Suppl 1):8-12. English, Portuguese. Epub 2020 May 18. PMID: 32428109; PMCID: PMC8149115.

SILVA, TO. Novos Paradigmas na Amiloidose Cardíaca: A Experiência Atual da Região Nordeste do Brasil. Arquivos Brasileiros de Cardiologia, v. 01, p. 112-113, 2021.

Silva, TDO, & Ritt, LEF. Parâmetros Ecocardiográficos Simples podem Substituir o Cálculo do Modelo Probabilístico ASCVD?. Arquivos Brasileiros de Cardiologia, 2022, 118, 925-926.

Fagundes A Jr, Berg DD, Park JG, Baird-Zars VM, Newby LK, Barsness GW, Miller PE, van Diepen S, Katz JN, Phreaner N, Roswell RO, Menon V, Daniels LB, Morrow DA, Bohula EA; CCCTN Investigators. Patients With Acute Coronary Syndromes Admitted to Contemporary Cardiac Intensive Care Units: Insights From the CCCTN Registry. Circ Cardiovasc Qual Outcomes. 2022 Aug;15(8):e008652. Epub 2022 Jul 5. PMID: 35862019.

Furtado RHM, Fagundes AA Jr, Oyama K, Zelniker TA, Tang M, Kuder JF, Murphy SA, Hamer A, Wang H, Keech AC, Giugliano RP, Sabatine MS, Bergmark BA. Effect of Evolocumab in Patients With Prior Percutaneous Coronary Intervention. Circ Cardiovasc Interv. 2022 Mar;15(3):e011382. Epub 2022 Feb 25. PMID: 35209731.

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Fagundes A Jr, Morrow DA, Oyama K, Furtado RHM, Zelniker TA, Tang M, Kuder JF, Murphy SA, Hamer A, Keech AC, Sever P, Giugliano RP, Sabatine MS, Bergmark BA. Biomarker Prediction of Complex Coronary Revascularization Procedures in the FOURIER Trial. J Am Coll Cardiol. 2022 Aug 30;80(9):887-897. PMID: 36007987.

Faria D, Moll-Bernardes RJ, Testa L, Moniz CMV, Rodrigues EC, Rodrigues AG, Araujo A, Alves MJNN, Ono BE, Izaias JE, Salemi VMC, Jordão CP, Amaro-Vicente G, Rondon MUPB, Ludwig KR, Craighead DH, Rossman MJ, Consolim-Colombo FM, De Angelis K, Irigoyen MCC, Seals DR, Negrão CE, Sales ARK. Sympathetic Neural Overdrive, Aortic Stiffening, Endothelial Dysfunction, and Impaired Exercise Capacity in Severe COVID-19 Survivors: A Mid-Term Study of Cardiovascular Sequelae. Hypertension. 2023 Feb;80(2):470-481. Epub 2022 Nov 23. PMID: 36416143; PMCID: PMC9847692.

Araujo GSM, Silva TOC, Guerra GM, Izaias JE, Rocha HMN, Faria D, Rocha NG, Dalmazo AL, Araujo A, Marciano Consolim-Colombo F, de Angelis K, Irigoyen MCC, Sales ARK. Effects of Postprandial Lipemia Combined With Disturbed Blood Flow on the Flow-Mediated Dilation, Oxidative Stress, and Endothelial Microvesicles in Healthy Subjects. Front Physiol. 2022 Feb 24;13:812942. PMID: 35283771; PMCID: PMC8907728.

Sales AR, Fernandes IA, Rocha NG, Costa LS, Rocha HN, Mattos JD, Vianna LC, Silva BM, Nóbrega AC. Aerobic exercise acutely prevents the endothelial dysfunction induced by mental stress among subjects with metabolic syndrome: the role of shear rate. Am J Physiol Heart Circ Physiol. 2014 Apr 1;306(7):H963-71. Epub 2014 Feb 14. PMID: 24531810.

Sales ARK, Negrão MV, Testa L, Ferreira-Santos L, Groehs RVR, Carvalho B, Toschi-Dias E, Rocha NG, Laurindo FRM, Debbas V, Rondon MUPB, Mano MS, Hajjar LA, Hoff PMG, Filho RK, Negrão CE. Chemotherapy acutely impairs neurovascular and hemodynamic responses in women with breast cancer. Am J Physiol Heart Circ Physiol. 2019 Jul 1;317(7):H1-H12. Epub 2019 Apr 19. PMID: 31002284.

Sales, A. R. K.; Azevedo, L. F; Silva, T. O. C; Gonzalez, A. R.; Oliveira, P. A; Jordao, C. P ; Andrade, A. C. ; Urias, U. ; Guimaraes, G. V. ; Alves MJN ; HAJJAR, L. A. ; Kalil Filho, R. ; Grunewald, Z. I. ; Martinez-lemus, Luis A. ; Padilla, Jaume ; Negrao, C. E. . High-intensity Interval Training Decreases Muscle Sympathetic Nerve Activity And Improves Peripheral Vascular Function In Patients With Heart Failure With Reduced Ejection Fraction. Circulation-heart Failure, V. 13, P. 13, 2020.

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Luca FAD, Arruda G, Esteves V, Feldman A, Sousa BS, Brandão JCV, Garcia RM, et al. Pulmonary Embolism in Patients with Covid-19 in Direct Oral Anticoagulant. Int J Cardiovasc Sci. 2021;35(1):140-4.

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