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Nossa equipe de neurologistas, psiquiatras, biólogos, psicólogos e outros especialistas estudam o desenvolvimento do sistema nervoso e seu funcionamento em condições normais e patológicas.

A pesquisa em neurociências é um dos carros-chefe do IDOR, desde a sua concepção. Uma das principais vertentes dessa área de pesquisa é o uso de células reprogramadas e organoides cerebrais para estudo do desenvolvimento e de doenças que acometem o sistema nervoso central. Células epiteliais extraídas da urina ou da pele de voluntários são induzidas a voltar ao estágio embrionário de células-tronco, capazes de se transformar em qualquer tecido humano, incluindo células do cérebro. Cultivadas em laboratório, essas células formam organoides cerebrais – também conhecidos como mini-cérebros – que permitem estudar em detalhe o desenvolvimento do sistema nervoso central e, também, o impacto de vírus como Zika e Sars-Cov-2, a manipulação de genes e os efeitos de medicamentos sobre o funcionamento do tecido nervoso.

Outra linha de pesquisa importante desenvolvida pelo IDOR na área neurociência é a de neuroimagem, em particular aplicada ao estudo da plasticidade cerebral, isto é, da capacidade que o cérebro humano tem de se adaptar a situações adversas. A integração entre os resultados de exames de imagens e dados clínicos, genéticos e laboratoriais permite estudar as doenças do sistema nervoso central de forma aprofundada, em três vertentes principais: doenças do neurodesenvolvimento, reabilitação e plasticidade no envelhecimento.

Com uso de exames de ressonância magnética funcional, os pesquisadores conseguem identificar as rotas de conexão entre as diferentes partes do cérebro saudável e em situações patológicas. Entre as condições estudadas estão a disgenesia do corpo caloso, os acidentes vasculares cerebrais e a síndrome do membro fantasma, que pode surgir após uma amputação.

Cientistas do IDOR estudam, ainda, novas técnicas capazes de ajudar pacientes a recuperarem suas funções cerebrais. Uma das técnicas estudadas é o neurofeedback, que usa a ressonância magnética funcional para mostrar aos pacientes sua atividade cerebral e estimulá-los a controlar essa atividade. 

O estudo de transtornos de aprendizagem e possíveis intervenções também faz parte do rol de pesquisas do IDOR voltadas à neurociência. Um exemplo é o desenvolvimento de um software  que visa auxiliar crianças neurotípicas e com dislexia e outros transtornos no aprendizado da leitura.

No Centro de Neuropsicologia Aplicada (CNA), o IDOR combina pesquisa científica e atendimento clínico, oferecendo serviço de investigação neuropsicológica a crianças, adolescentes e adultos com suspeita de transtornos de aprendizagem e atenção, problemas comportamentais e dificuldades de memória, entre outros. A equipe multidisciplinar do CNA lidera projetos de pesquisa sobre transtorno do déficit de atenção com hiperatividade e doença de Alzheimer.

Pesquisadores
Notícias Relacionadas
Principais Publicações

Manto M, Bower JM, Conforto AB, Delgado-García JM, da Guarda SN, Gerwig M, Habas C, Hagura N, Ivry RB, Mariën P, Molinari M, Naito E, Nowak DA, Oulad Ben Taib N, Pelisson D, Tesche CD, Tilikete C, Timmann D. Consensus paper: roles of the cerebellum in motor control–the diversity of ideas on cerebellar involvement in movement. Cerebellum. 2012 Jun;11(2):457-87. PMID: 22161499; PMCID: PMC4347949.

Farias da Guarda SN, Conforto AB. Effects of somatosensory stimulation on corticomotor excitability in patients with unilateral cerebellar infarcts and healthy subjects – preliminary results. Cerebellum Ataxias. 2014 Nov 5;1:16. Erratum in: Cerebellum Ataxias. 2016;3:11. PMID: 26331040; PMCID: PMC4552362.

Ramos JGR, da Hora Passos R, Teixeira MB, Gobatto ALN, Coutinho RVDS, Caldas JR, da Guarda SF, Ribeiro MP, Batista PBP. Prognostic ability of quick-SOFA across different age groups of patients with suspected infection outside the intensive care unit: A cohort study. J Crit Care. 2018 Oct;47:178-184. Epub 2018 Jul 7. PMID: 30005305.

Caldas JR, Passos RH, Ramos JGR, Ramalho C, Sancho LS, Salinet AM, Farias S, Gobatto A, Bombonato G, Benigno P, Taccone FS, Panerai RB. Dynamic Autoregulation is Impaired in Circulatory Shock. Shock. 2020 Aug;54(2):183-189. PMID: 31764617.

Farias DA Guarda SN, Santos JPS, Reis MSM, Passos RDH, Correia LC, Caldas JR, Gobatto ALN, Teixeira M, Oliveira A, Ribeiro MP, Batista PBP, Calderaro M, Paschoal Junior F, Pontes-Neto OM, Ramos JGR. Realistic simulation is associated with healthcare professionals’ increased self-perception of confidence in providing acute stroke care: a before-after controlled study. Arq Neuropsiquiatr. 2021 Jan;79(1):2-7. PMID: 33656107.

Drummond C, Coutinho G, Monteiro MC, Assuncao N, Teldeschi A, de Souza AS, Oliveira N, Bramati I, Sudo FK, Vanderboght B, Brandao CO, Fonseca RP, de Oliveira-Souza R, Moll J, Mattos P, Tovar-Moll F. Narrative impairment, white matter damage and CSF biomarkers in the Alzheimer’s disease spectrum. Aging (Albany NY). 2019;11(20):9188-9208.

Sudo FK, de Souza AS, Drummond C, Assuncao N, Teldeschi A, Oliveira N, Rodrigues F, Santiago-Bravo G, Calil V, Lima G, Erthal P, Bernardes G, Monteiro M, Tovar-Moll F, Mattos P. Inter-method and anatomical correlates of episodic memory tests in the Alzheimer’s Disease spectrum. PLoS One. 2019;14(10):e0223731.

Mendonca F, Sudo FK, Santiago-Bravo G, Oliveira N, Assuncao N, Rodrigues F, Soares R, Calil V, Bernardes G, Erthal P, Drummond C, Tovar-Moll F, Mattos P. Mild Cognitive Impairment or Attention-Deficit/Hyperactivity Disorder in Older Adults? A Cross Sectional Study. Front Psychiatry. 2021;12:737357. PMID: 34616321; PMCID: PMC8488111.

Pamplona FA, Vitória G, Sudo FK, Ribeiro FC, Isaac AR, Moraes CA, Chauvet MG, Ledur PF, Karmirian K, Ornelas IM, Leo LM, Paulsen B, Coutinho G, Drummond C, Assunção N, Vanderborght B, Canetti CA, Castro-Faria-Neto HC, Mattos P, Ferreira ST, Rehen SK, Bozza FA, Lourenco MV, Tovar-Moll F. Age-linked suppression of lipoxin A4 associates with cognitive deficits in mice and humans. Transl Psychiatry. 2022;12(1):439. PMID: 36216800; PMCID: PMC9551034.

Gonçalves RA, Sudo FK, Lourenco MV, Drummond C, Assunção N, Vanderborght B, Ferreira DDP, Ribeiro FC, Pamplona FA, Tovar-Moll F, Mattos P, Ferreira ST, De Felice FG. Cerebrospinal fluid irisin and lipoxin A4 are reduced in elderly Brazilian individuals with depression: Insight into shared mechanisms between depression and dementia. Alzheimers Dement. 2022. Epub ahead of print. PMID: 36465055.

Lourenco MV, Frozza RL, de Freitas GB, Zhang H, Kincheski GC, Ribeiro FC, Gonçalves RA, Clarke JR, Beckman D, Staniszewski A, Berman H, Guerra LA, Forny-Germano L, Meier S, Wilcock DM, de Souza JM, Alves-Leon S, Prado VF, Prado MAM, Abisambra JF, Tovar-Moll F, Mattos P, Arancio O, Ferreira ST, De Felice FG. Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models. Nature Medicine. 2019 Jan;25(1):165-175. Epub 2019 Jan 7. PMID: 30617325; PMCID: PMC6327967.

Sneddon, J., Daniel, E., Fischer, R., & Lee, J.A. (2022). The impact of the COVID-19 pandemic on environmental values. Sustainability Science. 17, 2155–2163.

Fischer, R., Karl, J. A., & Pilati, R. (2022). Cultural Syndromes in a Changing World: A Longitudinal Investigation of Brazilian Jeitinho Social Problem-Solving Strategies. Personality & Social Psychology Bulletin, 48(10), 1423–1437.

Fischer, R. & Karl, J.A. (2022). Unravelling values and wellbeing – disentangling within- and between-person dynamics via a psychometric network perspective. Journal of Personality and Social Psychology. Online ahead of print.

Ornelas IM, Cini FA, Wießner I, Marcos E, Araújo DB, Goto-Silva L, Nascimento J, Silva SRB, Costa MN, Falchi M, Olivieri R, Palhano-Fontes F, Sequerra E, Martins-de-Souza D, Feilding A, Rennó-Costa C, Tófoli LF, Rehen SK, Ribeiro S. Nootropic effects of LSD: Behavioral, molecular and computational evidence. Exp Neurol. 2022 Oct;356:114148. Epub 2022 Jun 19. PMID: 35732217.

Trindade P, Nascimento JM, Casas BS, Monteverde T, Gasparotto J, Ribeiro CT, Devalle S, Sauma D, Moreira JCF, Gelain DP, Porciuncula LO, Palma V, Martins-de-Souza D, Rehen SK. Induced pluripotent stem cell-derived astrocytes from patients with schizophrenia exhibit an inflammatory phenotype that affects vascularization. Mol Psychiatry. 2022 Oct 24. Epub ahead of print. PMID: 36280751.

da Hora Passos R, Caldas J, Ramos JGR, Dos Santos Galvão de Melo EB, Ribeiro MPD, Alves MFC, Batista PBP, Messeder OHC, de Carvalho de Farias AM, Macedo E, Rouby JJ. Ultrasound-based clinical profiles for predicting the risk of intradialytic hypotension in critically ill patients on intermittent dialysis: a prospective observational study. Crit Care. 2019 Dec 2;23(1):389. PMID: 31791373; PMCID: PMC6889608.

da Hora Passos R, Ramos JGR, Gobatto A, Caldas J, Macedo E, Batista PB. Inclusion and definition of acute renal dysfunction in critically ill patients in randomized controlled trials: a systematic review. Crit Care. 2018 Apr 24;22(1):106. PMID: 29690893; PMCID: PMC5979001.

da Hora Passos R, Ramos JG, Mendonça EJ, Miranda EA, Dutra FR, Coelho MF, Pedroza AC, Correia LC, Batista PB, Macedo E, Dutra MM. A clinical score to predict mortality in septic acute kidney injury patients requiring continuous renal replacement therapy: the HELENICC score. BMC Anesthesiol. 2017 Feb 7;17(1):21. PMID: 28173756; PMCID: PMC5297177.

Pedrosa, C. S. G.; Goto-Silva, L.; Temerozo, J.; Souza, L. R. Q.; Vitória, Gabriela; Ornelas, I.; Karmirian, K.; Mendes, M.; Gomes, I.; Sacramento, C.; Fintelman-Rodrigues, N.; Soares, V.; Dias, S.; Salerno, J.; Pijuan, T. P.; Oliveira, J. T.; Aragao, L.; Torquato, T.; Verissimo, C.; Biagi, D.; Cruvinel, E. M.; Dariolli, R.; Furtado, D.R.; Borges, H. L.; Bozza, P.; Rehen, S. K.; Souza, T. M.; Guimaraes, M. Z. P. Non-permissive SARS-CoV-2 infection in human neurospheres. Stem Cell Research., v.54, p.102436 – , 2021.

Guimarães, Marília Z. P.; De Vecchi, Rodrigo; Vitória, Gabriela; Sochacki, Jaroslaw K.; Paulsen, Bruna S.; Lima, Igor; Rodrigues Da Silva, Felipe; Da Costa, Rodrigo F. M.; Castro, Newton G.; Breton, Lionel; Rehen, Stevens K. Generation of iPSC-Derived Human Peripheral Sensory Neurons Releasing Substance P Elicited by TRPV1 Agonists. Frontiers in Molecular Neuroscience. , v.11, p.1 – 17, 2018.

Sartore, Rafaela C.; Cardoso, Simone C.; Lages, Yury V.M.; Paraguassu, Julia M.; Stelling, Mariana P.; Madeiro Da Costa, Rodrigo F.; Guimaraes, Marilia Z.; Pérez, Carlos A.; Rehen, Stevens K. Trace elements during primordial plexiform network formation in human cerebral organoids. PeerJ. , v.5, p.e2927, 2017.

Pamplona, F. A.; Ferreira, J.; Menezes De Lima, O.; Duarte, F. S.; Bento, A. F.; Forner, S.; Villarinho, J. G.; Bellochio, L.; Wotjak, C. T.; Lerner, R.; Monory, K.; Lutz, B.; Canetti, C.; Matias, I.; Calixto, J. B.; Marsicano, G.; Guimaraes, M. Z. P.; Takahashi, R. N. Anti-inflammatory lipoxin A4 is an endogenous allosteric enhancer of CB1 cannabinoid receptor. Proceedings of the National Academy of Sciences of the United States of America (Online). , v.109, p.21134 – 21139, 2012.

Marques-da-Silva, C; Chaves, MM; Castro, NG; Coutinho-Silva, R; Guimaraes, MZP Colchicine inhibits cationic dye uptake induced by ATP in P2X2 and P2X7 receptor-expressing cells: implications for its therapeutic action. British Journal of Pharmacology. v.163, p.912 – 926, 2011.

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Souza BSF, Silva DN, Carvalho RH, Sampaio GLA, Paredes BD, Aragão França L, Azevedo CM, Vasconcelos JF, Meira CS, Neto PC, Macambira SG, da Silva KN, Allahdadi KJ, Tavora F, de Souza Neto JD, Dos Santos RR, Soares MBP. Association of Cardiac Galectin-3 Expression, Myocarditis, and Fibrosis in Chronic Chagas Disease Cardiomyopathy. Am J Pathol. 2017 May;187(5):1134-1146. Epub 2017 Mar 17. PMID: 28322201.

Allahdadi KJ, de Santana TA, Santos GC, Azevedo CM, Mota RA, Nonaka CK, Silva DN, Valim CXR, Figueira CP, Dos Santos WLC, do Espirito Santo RF, Evangelista AF, Villarreal CF, Dos Santos RR, de Souza BSF, Soares MBP. IGF-1 overexpression improves mesenchymal stem cell survival and promotes neurological recovery after spinal cord injury. Stem Cell Res Ther. 2019 May 21;10(1):146. PMID: 31113444; PMCID: PMC6530133.

Rocha Ferreira GS, de Almeida JP, Landoni G, Vincent JL, Fominskiy E, Gomes Galas FRB, Gaiotto FA, Dallan LO, Franco RA, Lisboa LA, Palma Dallan LR, Fukushima JT, Rizk SI, Park CL, Strabelli TM, Gelas Lage SH, Camara L, Zeferino S, Jardim J, Calvo Arita ECT, Caldas Ribeiro J, Ayub-Ferreira SM, Costa Auler JO Jr, Filho RK, Jatene FB, Hajjar LA. Effect of a Perioperative Intra-Aortic Balloon Pump in High-Risk Cardiac Surgery Patients: A Randomized Clinical Trial. Crit Care Med. 2018 Aug;46(8):e742-e750. PMID: 29727370.

Caldas JR, Panerai RB, Bor-Seng-Shu E, Ferreira GSR, Camara L, Passos RH, de-Lima-Oliveira M, Galas FRBG, Almeida JP, Nogueira RC, Mian N, Gaiotto FA, Robinson TG, Hajjar LA. Dynamic cerebral autoregulation: A marker of post-operative delirium? Clin Neurophysiol. 2019 Jan;130(1):101-108. Epub 2018 Nov 22. PMID: 30503909; PMCID: PMC7106549.

Caldas JR, Panerai RB, Bor-Seng-Shu E, Ferreira GSR, Camara L, Passos RH, Salinet AM, Azevedo DS, de-Lima-Oliveira M, Galas FRBG, Fukushima JT, Nogueira R, Taccone FS, Landoni G, Almeida JP, Robinson TG, Hajjar LA. Intra-aortic balloon pump does not influence cerebral hemodynamics and neurological outcomes in high-risk cardiac patients undergoing cardiac surgery: an analysis of the IABCS trial. Ann Intensive Care. 2019 Nov 27;9(1):130. PMID: 31773324; PMCID: PMC6879692.

Caldas JR, Passos RH, Ramos JGR, Ramalho C, Sancho LS, Salinet AM, Farias S, Gobatto A, Bombonato G, Benigno P, Taccone FS, Panerai RB. Dynamic Autoregulation is Impaired in Circulatory Shock. Shock. 2020 Aug;54(2):183-189. PMID: 31764617.

Caldas JR, Panerai RB, Passos R, Hajjar LA. Is there still a place for transcranial Doppler in patients with IABP? Crit Care. 2020 Oct 23;24(1):625. PMID: 33097067; PMCID: PMC7585289.

Tovar-Moll, F. ; Monteiro, M. ; Andrade, J. ; Bramati, I. E. ; Vianna-Barbosa, R. ; Marins, T. ; Rodrigues, E. C. ; Dantas, N. ; Behrens, T. E. J. ; De Oliveira-Souza, R. ; Moll, J. ; Lent, R. . Structural and functional brain rewiring clarifies preserved interhemispheric transfer in humans born without the corpus callosum. Proceedings of the National Academy of Sciences of the United States of America, v. 111, p. 7843, 2014. PMID: 24821757; PMCID: PMC4040546.

Oliveira, LA ; Martins, C. ; Horsczaruk, C.H.R. ; Silva, D.C.S ; Vasconcellos, L. F. ; Lopes, A. J. ; Mainenti, M. R. M. ; Rodrigues, E.C. . Partial Body Weight-Supported Treadmill Training in Spinocerebellar Ataxia. Rehabilitation Research and Practice, v. 2018, p. 1-8, 2018.

Marins, T. ; Rodrigues, E.C. ; Bortolini, T. ; Melo, Bruno ; Moll, J. ; Tovar-Moll, F. . Structural and Functional Connectivity Changes in Response to Short-term Neurofeedback Training with Motor Imagery. Neuroimage, v. 194, p. 283, 2019.

Vieira, T. ; Carvalho, T. L. ; Oliveira, L. A. S. ; Horsczaruk, C. H. ; Freitas, G. R. ; Tovar-Moll, F ; Rodrigues, E.C. Postural Muscle Unit Plasticity in Stroke Survivors: Altered Distribution of Gastrocnemius’ Action Potentials. Frontiers in Neurology, v. 10, p. 686, 2019.

Evangelista, A.F.; Vannier-Santos, M.A.; de Assis Silva, G.S.; Silva, D. N.; Juiz, P. J. L.; Nonaka, C. K. V.; Santos, R.R; Soares, M.B.P Villarreal, C. F.Bone marrow-derived mesenchymal stem/stromal cells reverse the sensorial diabetic neuropathy via modulation of spinal neuroinflammatory cascades. J Neuroinflammation 15, 189 (2018).

Nonaka, C.K.V.; Sampaio, G.L.; de Aragão França, L.; Cavalcante, B.R.; Silva, K.N.; Khouri, R.; Torres, F.G.; Meira, C.S.; de Souza Santos, E.; Macedo, C.T.; Paredes, B.D.; Rocha, V.P.C.; Rogatto, S.R.; Ribeiro dos Santos, R.; Souza, B.S.d.F.; Soares, M.B.P. Therapeutic miR-21 Silencing Reduces Cardiac Fibrosis and Modulates Inflammatory Response in Chronic Chagas Disease. Int. J. Mol. Sci. 2021, 22, 3307.

Nonaka, C.K.V.; Macêdo, C.T.; Cavalcante, B.R.R.; Alcântara, A.C.d.; Silva, D.N.; Bezerra, M.d.R.; Caria, A.C.I.; Tavora, F.R.F.; Neto, J.D.d.S.; Noya-Rabelo, M.M.; Rogatto, S.R.; Ribeiro dos Santos, R.; Souza, B.S.d.F.; Soares, M.B.P. Circulating miRNAs as Potential Biomarkers Associated with Cardiac Remodeling and Fibrosis in Chagas Disease Cardiomyopathy. Int. J. Mol. Sci. 2019, 20, 4064.

Improta Caria, A.C.; Nonaka, C.K.V.; Pereira, C.S.; Soares, M.B.P.; Macambira, S.G.; Souza, B.S.d.F. Exercise Training-Induced Changes in MicroRNAs: Beneficial Regulatory Effects in Hypertension, Type 2 Diabetes, and Obesity. Int. J. Mol. Sci. 2018, 19, 3608.

Nonaka CKV, Franco MM, Gräf T, de Lorenzo Barcia CA, de Ávila Mendonça RN, de Sousa KAF, Neiva LMC, Fosenca V, Mendes AVA, de Aguiar RS, Giovanetti M, de Freitas Souza BS. Genomic Evidence of SARS-CoV-2 Reinfection Involving E484K Spike Mutation, Brazil. Emerg Infect Dis. 2021 May;27(5):1522-1524. Epub 2021 Feb 19. PMID: 33605869; PMCID: PMC8084516.

Silveira de Souza A., de Oliveira-Souza R., Moll J., Tovar-Moll F., Andreiuolo P.A., Bottino C.M.C.. Contribution of 1H Spectroscopy to a Brief Cognitive-Functional Test Battery for the Diagnosis of Mild Alzheimer’s Disease. Dement Geriatr Cogn Disord 2011;32:351–361.

Souza ASOliveira-Szjenfeld PS, Melo ASO,  Souza LAM, Batista AGM, Tovar-Moll F. Imaging findings in congenital Zika virus infection syndrome: an update. Child’s Nervous System 2018; 34:85-93.

Drummond C, Coutinho G, Monteiro MC, Assuncao N, Teldeschi A, de Souza AS, Oliveira N, Bramati I, Sudo FK, Vanderboght B, Brandao CO, Fonseca RP, de Oliveira-Souza R, et al. Narrative impairment, white matter damage and CSF biomarkers in the Alzheimer’s disease spectrum. Aging (Albany NY). 2019;11:9188-9208.

Sudo FK, de Souza AS, Drummond C, Assuncao N, Teldeschi A, Oliveira N, et al. Inter-method and anatomical correlates of episodic memory tests in the Alzheimer’s Disease spectrum. PLoS ONE 2019; 14(10): e0223731.

Calil V, Souza AS, Sudo FK, Santiago-Bravo G, Assunção N, Drummond C, et al. Anosognosia for memory in dementia with Lewy bodies compared with Alzheimer’s disease. International Journal of Geriatric Psychiatry 2021; 36(7):1059-1064.

Dakic V, Minardi Nascimento J, Costa Sartore R, Maciel RM, de Araujo DB, Ribeiro S, Martins-de-Souza D, Rehen SK. Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT. Sci Rep. 2017 Oct 9;7(1):12863. PMID: 28993683; PMCID: PMC5634411.

Garcez PP, Loiola EC, Madeiro da Costa R, Higa LM, Trindade P, Delvecchio R, Nascimento JM, Brindeiro R, Tanuri A, Rehen SK. Zika virus impairs growth in human neurospheres and brain organoids. Science. 2016 May 13;352(6287):816-8. Epub 2016 Apr 10. PMID: 27064148.

Pedrosa CDSG, Souza LRQ, Gomes TA, de Lima CVF, Ledur PF, Karmirian K, Barbeito-Andres J, Costa MDN, Higa LM, Rossi ÁD, Bellio M, Tanuri A, Prata-Barbosa A, Tovar-Moll F, Garcez PP, Lara FA, Molica RJR, Rehen SK. The cyanobacterial saxitoxin exacerbates neural cell death and brain malformations induced by Zika virus. PLoS Negl Trop Dis. 2020 Mar 12;14(3):e0008060. PMID: 32163415; PMCID: PMC7067372.

Tahira AC, Verjovski-Almeida S, Ferreira ST. Dementia is an age-independent risk factor for severity and death in COVID-19 inpatients. Alzheimers Dement. 2021 Nov;17(11):1818-1831. Epub 2021 Apr 21. PMID: 33881211; PMCID: PMC8250282.

Oliveira MM, Lourenco MV, Longo F, Kasica NP, Yang W, Ureta G, Ferreira DDP, Mendonça PHJ, Bernales S, Ma T, De Felice FG, Klann E, Ferreira ST. Correction of eIF2-dependent defects in brain protein synthesis, synaptic plasticity, and memory in mouse models of Alzheimer’s disease. Sci Signal. 2021 Feb 2;14(668):eabc5429. PMID: 33531382; PMCID: PMC8317334.

Figueiredo CP, Barros-Aragão FGQ, Neris RLS, Frost PS, Soares C, Souza INO, Zeidler JD, Zamberlan DC, de Sousa VL, Souza AS, Guimarães ALA, Bellio M, Marcondes de Souza J, Alves-Leon SV, Neves GA, Paula-Neto HA, Castro NG, De Felice FG, Assunção-Miranda I, Clarke JR, Da Poian AT, Ferreira ST. Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice. Nat Commun. 2019 Sep 5;10(1):3890. PMID: 31488835; PMCID: PMC6728367.

Lourenco MV, Frozza RL, de Freitas GB, Zhang H, Kincheski GC, Ribeiro FC, Gonçalves RA, Clarke JR, Beckman D, Staniszewski A, Berman H, Guerra LA, Forny-Germano L, Meier S, Wilcock DM, de Souza JM, Alves-Leon S, Prado VF, Prado MAM, Abisambra JF, Tovar-Moll F, Mattos P, Arancio O, Ferreira ST, De Felice FG. Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models. Nat Med. 2019 Jan;25(1):165-175. Epub 2019 Jan 7. PMID: 30617325; PMCID: PMC6327967.

Ledo JH, Azevedo EP, Beckman D, Ribeiro FC, Santos LE, Razolli DS, Kincheski GC, Melo HM, Bellio M, Teixeira AL, Velloso LA, Foguel D, De Felice FG, Ferreira ST. Cross Talk Between Brain Innate Immunity and Serotonin Signaling Underlies Depressive-Like Behavior Induced by Alzheimer’s Amyloid-β Oligomers in Mice. J Neurosci. 2016 Nov 30;36(48):12106-12116. PMID: 27903721; PMCID: PMC6601978.

Fischer, R.& Karl, J.A. (2021). Predicting behavioral intentions to prevent or mitigate COVID-19: A cross-cultural meta-analysis of attitudes, norms and perceived behavioral control effects. Social Psychological and Personality Science, 13 (1), 264-276.

Brockington, G., Moreira, A. P.G., Buso, M.S., Gomes da Silva, S., Altszyler, E., Fischer, R., &  Moll, J. (2021). Storytelling increases oxytocin and positive emotions and decreases cortisol and pain in hospitalized children. Proceedings of the National Academy of Sciences, Jun 2021, 118 (22) e2018409118;

Daniel, E., Bardi, A., Fischer, R., Benish-Weisman, M. & Lee, J.A. (2021). Changes in personal values in pandemic times. Social Psychological and Personality Science. 13(2), 572–582.

Azevedo FA, Carvalho LR, Grinberg LT, Farfel JM, Ferretti RE, Leite RE, Jacob Filho W, Lent R, Herculano-Houzel S. Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain. J Comp Neurol. 2009 Apr 10;513(5):532-41. PMID: 19226510.

Lent R, Azevedo FA, Andrade-Moraes CH, Pinto AV. How many neurons do you have? Some dogmas of quantitative neuroscience under revision. Eur J Neurosci. 2012 Jan;35(1):1-9. Epub 2011 Dec 13. PMID: 22151227.

Andrade-Moraes CH, Oliveira-Pinto AV, Castro-Fonseca E, da Silva CG, Guimarães DM, Szczupak D, Parente-Bruno DR, Carvalho LR, Polichiso L, Gomes BV, Oliveira LM, Rodriguez RD, Leite RE, Ferretti-Rebustini RE, Jacob-Filho W, Pasqualucci CA, Grinberg LT, Lent R. Cell number changes in Alzheimer’s disease relate to dementia, not to plaques and tangles. Brain. 2013 Dec;136(Pt 12):3738-52. Epub 2013 Oct 17. PMID: 24136825; PMCID: PMC3859218.

Tovar-Moll F, Monteiro M, Andrade J, Bramati IE, Vianna-Barbosa R, Marins T, Rodrigues E, Dantas N, Behrens TE, de Oliveira-Souza R, Moll J, Lent R. Structural and functional brain rewiring clarifies preserved interhemispheric transfer in humans born without the corpus callosum. Proc Natl Acad Sci U S A. 2014 May 27;111(21):7843-8. Epub 2014 May 12. PMID: 24821757; PMCID: PMC4040546.

Szczupak D, Liu C, Yen CCC, Choi SH, Meireles F, Victorino C; IRC5 Consortium; Richards L, Lent R, Silva AC, Tovar-Moll F. Long-distance aberrant heterotopic connectivity in a mouse strain with a high incidence of callosal anomalies. Neuroimage. 2020 Aug 15;217:116875. Epub 2020 Apr 23. PMID: 32335262; PMCID: PMC7590260.

Moll J, de Oliveira-Souza R, Basilio R, Bramati IE, Gordon B, Rodríguez-Nieto G, Zahn R, Krueger F, Grafman J. Altruistic decisions following penetrating traumatic brain injury. Brain. 2018 May 1;141(5):1558-1569. PMID: 29590314; PMCID: PMC7341482.

de Oliveira-Souza R. Phobia of the Supernatural: A Distinct but Poorly Recognized Specific Phobia With an Adverse Impact on Daily Living. Front Psychiatry. 2018 Nov 16;9:590. PMID: 30505286; PMCID: PMC6250805.

de Oliveira-Souza R, Paranhos T, Moll J, Grafman J. Gender and Hemispheric Asymmetries in Acquired Sociopathy. Front Psychol. 2019 Mar 19;10:346. PMID: 30941065; PMCID: PMC6433972.

de Oliveira-Souza R, Moll J, Zahn R. Moral cognition in neurology. In: Reference Module in Neuroscience and Biobehavioral Psychology. New York, NY: Elsevier, 2020: 1-7

Prado CSC, Lopes PMG, Moll J, DeSalles A, de Oliveira-Souza R. A case of developmental pedophilia unmasked by frontotemporal dementia. Neurocase, 2021; 27 (2): 129-137

Drummond C, Coutinho G, Monteiro MC, Assuncao N, Teldeschi A, de Souza AS, Oliveira N, Bramati I, Sudo FK, Vanderboght B, Brandao CO, Fonseca RP, de Oliveira-Souza R, Moll J, Mattos P, Tovar-Moll F. Narrative impairment, white matter damage and CSF biomarkers in the Alzheimer’s disease spectrum. Aging (Albany NY). 2019 Oct 31;11(20):9188-9208. Epub 2019 Oct 31. PMID: 31682234; PMCID: PMC6834410.

Nazar BP, Bernardes C, Peachey G, Sergeant J, Mattos P, Treasure J. The risk of eating disorders comorbid with attention-deficit/hyperactivity disorder: A systematic review and meta-analysis. Int J Eat Disord. 2016 Dec;49(12):1045-1057. doi: 10.1002/eat.22643. Epub 2016 Nov 15. PMID: 27859581.

Faraone SV et al., The World Federation of ADHD International Consensus Statement: 208 Evidence-based conclusions about the disorder. Neuroscience and Biobehavioral Reviews. Volume 128, 2021, Pages 789-818, ISSN 0149-7634.

Thompson EM, Destree L, Albertella L, Fontenelle LF. Internet-Based Acceptance and Commitment Therapy: A Transdiagnostic Systematic Review and Meta-Analysis for Mental Health Outcomes. Behav Ther. 2021 Mar;52(2):492-507.

Fontenelle LF, Destrée L, Brierley ME, Thompson EM, Yücel M, Lee R, Albertella L, Chamberlain SR. The place of obsessive-compulsive and related disorders in the compulsive-impulsive spectrum: a cluster-analytic study. CNS Spectr. 2021 Apr 12:1-10.

Fontenelle LF, Albertella L, Brierley ME, Thompson EM, Destrée L, Chamberlain SR, Yücel M. Correlates of obsessive-compulsive and related disorders symptom severity during the COVID-19 pandemic. J Psychiatr Res. 2021 Apr 13:S0022-3956(21)00198-9.

Brierley ME, Thompson EM, Albertella L, Fontenelle LF. Lifestyle interventions in the treatment of Obsessive-Compulsive and Related Disorders: A systematic review. Psychosom Med. 2021 Jul 23.

Yücel M, Lee RSC, Fontenelle LF. A New Consensus Framework for Phenotyping and Treatment Selecting in Addiction and Obsessive-Compulsive-Related Disorders. JAMA Psychiatry. 2021 Jul 1;78(7):699-700.

Brockington, G, Moreira, APG, Busoc, MS, da Silva SG, Altszylerg E, Fischerh R, and Moll J. Storytelling increases oxytocin and positive emotions and decreases cortisol and pain in hospitalized children. Proceedings of the National Academy of Sciences, 118(22):e2018409118, 2021. PMID: 34031240; PMCID: PMC8179166.

Moll, J, de Oliveira-Souza R, Basilio R, Bramati IE, Gordon B, Rodríguez-Nieto G, Zahn R, Krueger F, Grafman J. Altruistic decisions following penetrating traumatic brain injury. Brain 141(5), 1558-1569, 2018.

Moll, Jorge; Krueger, Frank; Zahn, Roland; Pardini, Matteo; de Oliveira-Souza, Ricardo; Grafman, Jordan. Human fronto–mesolimbic networks guide decisions about charitable donation. Proceedings of the National Academy of Sciences 103 (42), 15623-15628, 2006.  Epub 2006 Oct 9. PMID: 17030808; PMCID: PMC1622872

Moll, Jorge; de Oliveira-Souza, Ricardo; Eslinger, Paul J.; Bramati, Ivanei E. et al. The neural correlates of moral sensitivity: a functional magnetic resonance imaging investigation of basic and moral emotions. The Journal of Neuroscience, 22 (7), 2730-2736, 2002.

Moll, Jorge; Zahn, Roland; de Oliveira-Souza, Ricardo; Krueger, Frank; Grafman, Jordan. The neural basis of human moral cognition. Nature Reviews Neuroscience 6 (10), 799-809, 2005.

De Felice FG, Tovar-Moll F, Moll J, Munoz DP & Ferreira ST. (2020) Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the Central Nervous System. Trends in Neuroscience, 43(6):355-357.

Bomfim TR, Forny-Germano L, Sathler LB, Brito-Moreira J, Houzel JC, Decker H, Silverman MA, Kazi H, Melo HM, McClean PL, Holscher C, Arnold SE, Talbot K, Klein WL, Munoz DP, Ferreira ST, De Felice FG. An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease- associated Aβ oligomers. J Clin Invest, 122(4): 1339-1353, 2012. Commentaries in Nat Rev Neurol, Sci Transl Med and J Clin Invest.

Lourenco MV, Clarke JR, Frozza RL, Bomfim TR, Forny-Germano L, Batista AF, Sathler LB, Brito-Moreira J, Amaral OB, Silva CA, Freitas-Correa L, Espírito-Santo S, Campello-Costa P, Houzel JC, Klein WL, Holscher C, Carvalheira JB, Silva AM, Velloso LA, Munoz DP, Ferreira ST, De Felice FG. TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer’s β-amyloid oligomers in mice and monkeys. Cell Metab, 18(6): 831-843, 2013. Cover story, Commentary in Cell Metab.

Lourenco MV, Frozza RL, de Freitas GB, Zhang H, Kincheski GC, Clarke JR, Ribeiro FC, Beckman D, Staniszevski A, Berman HL, Guerra LA, Forny-Germano L, Meier S, Abisambra JF, Wilcock DM, Prado VF, Prado MAM, de Souza JM, Alves-Leon SV, Tovar-Moll F, Mattos P, Arancio O, Ferreira ST, De Felice FG. Exercise-linked FNDC5/irisin rescues synapse and memory defects in Alzheimer’s models. Nature Medicine, 25(1):165-175, 2019. Commented in Nature Medicine, Nature Reviews Drug Discovery and Alzforum. 

Melo HM, Seixas da Silva GS, Costa B, Clarke JR, Figueiredo CP, Klein WL, Checler F, Velloso LA, Balthazar M, Cintra D, Ferreira ST, De Felice FG*. (2020) Palmitate is increased in the cerebrospinal fluid of humans with obesity and induces memory impairment in mice via pro-inflammatory TNF-α. Cell Reports, 30;2180-2194.

Szczupak D, Liu C, Yen CCC, Choi SH, Meireles F, Victorino C; IRC5 Consortium, Richards L, Lent R, Silva AC, Tovar-Moll F. Long-distance aberrant heterotopic connectivity in a mouse strain with a high incidence of callosal anomalies. Neuroimage. 2020 Aug 15;217:116875.

T Marins, EC Rodrigues, T Bortolini, B Melo, J Moll, F Tovar-Moll. Structural and functional connectivity changes in response to short-term neurofeedback training with motor imagery. Neuroimage. 2019;194, 283-290.

Soares de Oliveira-Szejnfeld P, Levine D, Melo AS, Amorim MM, Batista AG, Chimelli L, Tanuri A, Aguiar RS, Malinger G, Ximenes R, Robertson R, Szejnfeld J, Tovar-Moll F. Congenital Brain Abnormalities and Zika Virus: What the Radiologist Can Expect to See Prenatally and Postnatally. Radiology. 2016; 1(1), 203-18.

Tovar-Moll F, Monteiro M, Andrade J, Bramati IE, Vianna-Barbosa R, Marins T, Rodrigues E, Dantas N, Behrens TE, de Oliveira-Souza R, et al. Structural and functional brain rewiring clarifies preserved interhemispheric transfer in humans born without the corpus callosum. Proc Natl Acad Sci U S A. 2014; 111(21), 7843-8.

Simões EL, Bramati I, Rodrigues E, Franzoi A, Moll J, Lent R, Tovar-Moll F. Functional expansion of sensorimotor representation and structural reorganization of callosal connections in lower limb amputees. J Neurosci. 2012; 32(9), 3211-20.

Martins-de-Souza D, Maccarrone G, Ising M, Kloiber S, Lucae S, Holsboer F, Turck CW. Blood mononuclear cell proteome suggests integrin and Ras signaling as critical pathways for antidepressant treatment response. Biol Psychiatry. 2014 Oct 1;76(7):e15-7.

Cassoli JS, Brandão-Teles C, G Santana A, H M F Souza G, Martins-de-Souza D. Ion Mobility-Enhanced Data-Independent Acquisitions Enable a Deep Proteomic Landscape of Oligodendrocytes. Proteomics. 2017 Nov;17(21).

Nascimento JM, Saia-Cereda VM, Sartore RC, da Costa RM, Schitine CS,Freitas HR, Murgu M, de Melo Reis RA, Rehen SK, Martins-de-Souza D. Human Cerebral Organoids and Fetal Brain Tissue Share Proteomic Similarities. Front Cell Dev Biol. 2019 Nov 28;7:303.

Garcia-Rosa S, Carvalho BS, Guest PC, Steiner J, Martins-de-Souza D. Blood plasma proteomic modulation induced by olanzapine and risperidone in schizophrenia patients. Proteomics. 2020 Jul 30;224:103813.

Falvella ACB, Smith BJ, Silva-Costa LC, Valença AGF, Crunfli F, Zuardi AW, Hallak JE, Crippa JA, de Almeida V, Martins-de-Souza D. Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144.

Souza BS, Sampaio GL, Pereira CS, Campos GS, Sardi SI, Freitas LA, Figueira CP, Paredes BD, Nonaka CK, Azevedo CM, Rocha VP, Bandeira AC, Mendez-Otero R, Dos Santos RR, Soares MB. Zika virus infection induces mitosis abnormalities and apoptotic cell death of human neural progenitor cells. Scientific reports 6 (1), 1-13. 2016. PMID: 28008958; PMCID: PMC5180086.

Sampaio GLA, Martins GLS, Paredes BD, Nonaka CKV, da Silva KN, Rossi EA, Dos Santos RR, Soares MBP, Souza BSF. Generation of an induced pluripotent stem cell line from a patient with autism spectrum disorder and SCN2A haploinsufficiency. Stem Cell Research. Volume 39, August 2019, 101488. Epub 2019 Jun 25. PMID: 31272037.

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